个人科研网厅 | | 帮助
高级检索
当前位置： 首页 > 详情页

Identification of Novel Risk Loci for Behcet's Disease-Related Uveitis in a Chinese Population in a Genome-Wide Association Study

| 认领 | 导出 | |

文献详情

资源类型：
WOS体系：

收录情况： ◇ SCIE

作者：
Su, Guannan[1,2] * ; Zhong, Zhenyu[1,2] * ; Zhou, Qingyun[1,2] * ; Du, Liping[3] * ; Ye, Zi[1,2] ; Li, Fuzhen[3] ; Zhuang, Wenjuan[4] ; Wang, Chaokui[1,2] ; Liang, Liang[1,2] ; Ji, Yan[1,2] ; Cao, Qingfeng[1,2] ; Wang, Qingfeng[1,2] ; Chang, Rui[1,2] ; Tan, Handan[1,2] ; Yi, Shenglan[1,2] ; Li, Yujing[1,2] ; Feng, Xiaojie[1,2] ; Liao, Weiting[1,2] ; Zhang, Wanyun[1,2] ; Shu, Jia[1,2] ; Tan, Shiyao[1,2] ; Xu, Jing[1,2] ; Pan, Su[1,2] ; Li, Hongxi[1,2] ; Shi, Jing[1,2] ; Chen, Zhijun[1,2] ; Zhu, Ying[1,2] ; Ye, Xingsheng[1,2] ; Tan, Xiao[1,2] ; Zhang, Jun[1,2] ; Liu, Zhangluxi[1,2] ; Huang, Fanfan[1,2] ; Yuan, Gangxiang[1,2] ; Pang, Tingting[3] ; Liu, Yizong[3] ; Ding, Jiadong[3] ; Gao, Yingnan[3] ; Zhang, Meifen[5] ; Chi, Wei[6] ; Liu, Xiaoli[7] ; Wang, Yuqin[8] ; Chen, Ling[9] ; Meguro, Akira[10] ; Takeuchi, Masaki[10] ; Mizuki, Nobuhisa[10] ; Ohno, Shigeaki[11] ; Zuo, Xianbo[12,13,*2] ; Kijlstra, Aize[14] ; Yang, Peizeng[1,2,*1] ;
单位： [1]Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China [2]Natl Clin Res Ctr Ocular Dis, Chongqing Branch, Chongqing, Peoples R China [3]Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou, Peoples R China [4]Peoples Hosp Ningxia Hui Autonomous Reg, Yinchuan, Ningxia, Peoples R China [5]Peking Union Med Coll Hosp, Beijing, Peoples R China [6]Sun Yat Sen Univ, Guangzhou, Peoples R China [7]Jilin Univ, Changchun, Peoples R China [8]Wenzhou Med Univ, Eye Hosp, Wenzhou, Peoples R China [9]Fudan Univ, Eye & ENT Hosp, Shanghai, Peoples R China [10]Yokohama City Univ, Sch Med, Yokohama, Kanagawa, Japan [11]Hokkaido Univ, Sapporo, Hokkaido, Japan [12]China Japan Friendship Hosp, Beijing, Peoples R China [13]Anhui Med Univ, 1 Hosp, Hefei, Anhui, Peoples R China [14]Univ Eye Clin Maastricht, Maastricht, Netherlands
出处：
DOI： 10.1002/art.41998
ISSN：

摘要：
Objective. To explore susceptibility loci associated with uveitis in Behcet's disease (BD). Methods. We conducted a 2-stage study, consisting of a genome-wide association study (GWAS) stage and a replication stage, in a Chinese population. The GWAS stage included 978 cases with BD-related uveitis and 4,388 controls, and the replication stage included 953 cases with BD-related uveitis and 2,129 controls. Luciferase reporter analysis and chromatin immunoprecipitation assay were performed to explore the functional role of susceptibility genetic variants near ZMIZ1. Results. Three independent HLA alleles (HLA-B51 [3.75 x 10(-190)], HLA-A26 [1.50 x 10(-18)], and HLA-C0704 [3.44 x 10(-16)]) were identified as having a genome-wide association with BD-related uveitis. In the non-HLA region, in addition to confirming 7 previously reported loci, we identified 22 novel susceptibility variants located in 16 loci. Meta-analysis of the Chinese cohort consisting of 1,931 cases and 6,517 controls and a published Japanese cohort of 611 cases and 737 controls showed genome-wide significant associations with ZMIZ1, RPS6KA4, IL10RA, SIPA1-FIBP-FOSL1, and VAMP1. Functional experiments demonstrated that genetic variants of ZMIZ1 were associated with enhanced transcription activity and increased expression of ZMIZ1. Conclusion. This GWAS study identified a novel set of genetic variants that are associated with susceptibility to uveitis in BD. These findings enrich our understanding of the contribution of genetic factors to the disease.

基金：
Supported by the Natural Science Foundation Major International (Regional) Joint Research Project (81720108009), National Natural Science Foundation Key Program (81930023), Chongqing Outstanding Scientists Project (2019), Chongqing Key Laboratory of Ophthalmology (CSTC, 2008CA5003), Chongqing Science & Technology Platform and Base Construction Program (cstc2014pt-sy10002), Chongqing Chief Medical Scientist Project (2018), National Natural Science Foundation Project (81800816), and National Key Research and Development Plan for Precision Medicine Research (2017YFC0910002).
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 1 区 医学
小类 | 1 区 风湿病学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 风湿病学
JCR分区：
出版当年[2020]版：
Q1 RHEUMATOLOGY
最新[2023]版：
Q1 RHEUMATOLOGY

影响因子： 最新[2023版] 最新五年平均[2021-2025] 出版当年[2020版] 出版当年五年平均[2016-2020] 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者单位： [1]Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China [2]Natl Clin Res Ctr Ocular Dis, Chongqing Branch, Chongqing, Peoples R China
共同第一作者：
通讯作者：
通讯机构： [1]Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China [2]Natl Clin Res Ctr Ocular Dis, Chongqing Branch, Chongqing, Peoples R China [12]China Japan Friendship Hosp, Beijing, Peoples R China [13]Anhui Med Univ, 1 Hosp, Hefei, Anhui, Peoples R China [*1]Peizeng No. 1 Friendship Road, Yuanjiagang, Yuzhong District Chongqing, China 400016 [*2]Yinghuadongjie No. 2, Chaoyang District, Beijing, China, 100029
推荐引用方式(GB/T 7714)：
Su Guannan,Zhong Zhenyu,Zhou Qingyun,et al.Identification of Novel Risk Loci for Behcet's Disease-Related Uveitis in a Chinese Population in a Genome-Wide Association Study[J].ARTHRITIS & RHEUMATOLOGY.2022,74(4):671-681.doi:10.1002/art.41998.
APA：
Su, Guannan,Zhong, Zhenyu,Zhou, Qingyun,Du, Liping,Ye, Zi...&Yang, Peizeng.(2022).Identification of Novel Risk Loci for Behcet's Disease-Related Uveitis in a Chinese Population in a Genome-Wide Association Study.ARTHRITIS & RHEUMATOLOGY,74,(4)
MLA：
Su, Guannan,et al."Identification of Novel Risk Loci for Behcet's Disease-Related Uveitis in a Chinese Population in a Genome-Wide Association Study".ARTHRITIS & RHEUMATOLOGY 74..4(2022):671-681

资源点击量：1320 今日访问量：0 总访问量：816 更新日期：2025-04-01 建议使用谷歌、火狐浏览器 常见问题

版权所有：重庆聚合科技有限公司 渝ICP备12007440号-3 地址：重庆市两江新区泰山大道西段8号坤恩国际商务中心16层（401121）