单位：[1]Fudan University, 12478, Shanghai, China.[2]National Clinical Research Center for Respiratory Diseases, Center for Respiratory Diseases, China－Japan Friendship Hospital; Department of Pulmonary and Critical Care Medicine, China－Japan Friendship Hospital; Peking University Health Science Center, Beijing, China.[3]China-Japan Friendship Hospital, Beijing, China.[4]School of Public Health, Fudan University, Shanghai, China.[5]Shanxi Dayi Hospital, Taiyuan, China.[6]The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.[7]Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Department of Respiratory and Critical Care Medicine, Wuhan, China.华中科技大学同济医学院附属同济医院[8]Guizhou Provincial People's Hospital, Guiyang, China.[9]Zhongshan Hospital, Fudan University, Pulmonary medicnie, Shanghai, China.[10]The First Hospital of China Medical University, Shenyang, China.[11]State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.[12]Zhejiang University School of Medicine, Respiratory and Critical Care Medicine, Hangzhou, China.[13]State Key Lab for Respiratory Diseases, Guangzhou, China.[14]West China Hospital of Sichuan University, Chengdu, China.四川大学华西医院[15]Capital Medical University, 12517, Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Beijing, China.北京朝阳医院[16]Peking University,Third Hospital, Respiratory Department, Beijing, China.[17]Beijing Hospital, 117555, Beijing, China.[18]Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medical Sciences, 196536, Beijing, China.[19]Beijing Chao-Yang Hospital, 74639, Beijing, China.北京朝阳医院[20]China-Japan Friendship Hospital, 36635, Beijing, China.[21]National Center of Gerontology, Beijing, China.[22]The First Affiliated Hospital of Xi'an Jiaotong University, xi'an, China.[23]Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.华中科技大学同济医学院附属同济医院[24]Zhongshan Hospital, Fudan University, Department of Pulmonary medicnie, Shanghai, China.[25]The First Hospital of China Medical University, 159407, Department of Pulmonary and Critical Care Medicine, Shenyang, China.[26]The First Affiliated Hospital, Guangzhou Medical University, Guangzhou Institute of Respiratory Diseases, State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital, Department of Laboratory Medicine, Guangzhou, China.[27]Zhejiang University School of Medicine Second Affiliated Hospital, 89681, Hangzhou, China.[28]Sichuan University West China Hospital, 34753, Chengdu, China.[29]Beijing Hospital, Department of Pulmonary and Critical Care Medicine, Beijing, China.[30]Beijing Hospital, Beijing Institute of Geriatrics, Beijing, China.[31]Beijing Chao-Yang Hospital, Department of Pulmonary and Critical Care Medicine, Beijing, China.北京朝阳医院[32]Beijing Institute of Respiratory Diseases, 74699, Department of Pulmonary and Critical Care Medicine, Beijing, China.北京朝阳医院[33]Beijing Children's Hospital, 117984, Beijing, China.首都医科大学附属北京儿童医院[34]Peking Union Medical College School of Basic Medicine, 196536, Beijing, China.[35]Beijing Chao Yang Hospital,Capital Medical University, Beijing Institute of Respiratory Medicine, Beijing, China.北京朝阳医院[36]Beijing Institute of Respiratory Medicine, Beijing, China.北京朝阳医院[37]Beijing Chao-Yang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University, Beijing, China.北京朝阳医院[38]Tongji Medical College, HUST, Institute of Occupational Medicine, Wuhan, China.[39]Tulane University School of Public Health and Tropical Medicine, Epidemiology, New Orleans, Louisiana, United States.[40]Harvard University, 1812, Cambridge, Massachusetts, United States.[41]Fudan University, 12478, Department of Environmental Health, Shanghai, China.[42]Beijing Chaoyang Hospital-Affiliate of Capital University of Medical Sciences, Beijing, China; cyh-birm@263.net.北京朝阳医院
It remains unknown whether long-term ozone exposure can impair lung function.To investigate the associations between long-term ozone exposure and adult lung function in China.Lung function results and diagnosis of small airways dysfunction (SAD) were collected from a cross-sectional study, China Pulmonary Health Study (N=50,991). We used multivariate linear and logistic regression models to examine the associations of long-term ozone exposure with lung function parameters and SAD, respectively, adjusting for demographic characteristics, individual risk factors, and longitudinal trend. We then performed a stratification analysis by chronic obstructive pulmonary disease (COPD).We observed each 1-standard deviation (SD, 4.9 ppb) increase in warm-season ozone concentrations was associated with a 14.2 mL/s [95% confidence interval (CI): 8.8, 19.6] decrease in forced expiratory flow at 75th percentile of vital capacity and a 29.5 mL/s (95% CI: 19.6, 39.5) decrease in mean forced expiratory flow between the 25th and 75th percentile of vital capacity. The odds ratio of SAD was 1.09 (95% CI: 1.06, 1.11) for a 1-SD increase in warm-season ozone concentrations. Meanwhile, we observed a significant association with a decreased ratio of expiratory volume in 1 second to forced vital capacity (FEV1/FVC) but not with FEV1 or FVC. The association estimates were greater in the COPD group than in the non-COPD group.We found independent associations of long-term ozone exposure with impaired small airways function and higher SAD risks, while the associations with airflow obstruction were weak. COPD patients appear to be more vulnerable.
Niu Yue,Yang Ting,Gu Xiaoying,et al.Long-term Ozone Exposure and Small Airways Dysfunction: The China Pulmonary Health (CPH) Study.[J].American Journal of Respiratory and Critical Care Medicine.2021,doi:10.1164/rccm.202107-1599OC.
APA：
Niu Yue,Yang Ting,Gu Xiaoying,Chen Renjie,Meng Xia...&.(2021).Long-term Ozone Exposure and Small Airways Dysfunction: The China Pulmonary Health (CPH) Study..American Journal of Respiratory and Critical Care Medicine,,
MLA：
Niu Yue,et al."Long-term Ozone Exposure and Small Airways Dysfunction: The China Pulmonary Health (CPH) Study.".American Journal of Respiratory and Critical Care Medicine .(2021)
医学