单位：[1]Department of Surgical Intensive Care Unit, Beijing An Zhen Hospital, Capital Medical University, Beijing 100029, China.首都医科大学附属安贞医院[2]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, National Clinical Research Center for Respiratory Disease, Beijing 100029, China.[3]National Clinical Research Center for Respiratory Diseases, Beijing 100029, China.
Our work focused on alveolar epithelial cells (AECs)-derived type-2 cytokine (interleukin [IL]-25) in the pathogenesis of idiopathic pulmonary fibrosis (IPF). We showed that IL-25 and IL-17BR (IL-25's receptor) is upregulated in lung tissues (especially in AECs and lung fibroblasts) of IPF patients and contributes to lung fibrosis by directly activating lung fibroblasts and modulating epithelial-mesenchymal transition (EMT) of AECs. We suggest that IL-25 may be one of the master switches hidden in the milieu of abnormal epithelial-mesenchymal crosstalk. Treatment targeting IL-25 may be the potential and novel method for IPF patients.
基金：
National Natural
Science Foundation of China (81470258) and by Science
Foundation initiated by Capital Medical University, Beijing,
China (PYZ2017024)
第一作者单位：[1]Department of Surgical Intensive Care Unit, Beijing An Zhen Hospital, Capital Medical University, Beijing 100029, China.
通讯作者：
通讯机构：[2]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, National Clinical Research Center for Respiratory Disease, Beijing 100029, China.[3]National Clinical Research Center for Respiratory Diseases, Beijing 100029, China.
推荐引用方式(GB/T 7714)：
Xu Xuefeng,Luo Sa,Li Biyun,et al.IL-25 contributes to lung fibrosis by directly acting on alveolar epithelial cells and fibroblasts.[J].Experimental Biology And Medicine (Maywood, N.J.).2019,244(9):770-780.doi:10.1177/1535370219843827.
APA：
Xu Xuefeng,Luo Sa,Li Biyun,Dai Huaping&Zhang Jinglan.(2019).IL-25 contributes to lung fibrosis by directly acting on alveolar epithelial cells and fibroblasts..Experimental Biology And Medicine (Maywood, N.J.),244,(9)
MLA：
Xu Xuefeng,et al."IL-25 contributes to lung fibrosis by directly acting on alveolar epithelial cells and fibroblasts.".Experimental Biology And Medicine (Maywood, N.J.) 244..9(2019):770-780
