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Alterations of monoamine neurotransmitters, HPA-axis hormones, and inflammation cytokines in reserpine-induced hyperalgesia and depression comorbidity rat model.

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收录情况： ◇ SCIE

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单位： [1]Department of Traditional Chinese Medicine, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong-an Road, Beijing, 100050, China. [2]Department of Integrated Traditional and Western Medicine, Capital Medical University, Beijing, 100050, China. [3]Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. [4]Department of Traditional Chinese Medicine, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong-an Road, Beijing, 100050, China. lili@ccmu.edu.cn. [5]Department of Integrated Traditional and Western Medicine, Capital Medical University, Beijing, 100050, China. lili@ccmu.edu.cn.

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摘要：

Pain and depression often occur simultaneously, but the mechanism of this condition is still unclear.The aim of this study was to examine the alterations of monoamine neurotransmitters, hypothalamic-pituitary-adrenal (HPA) axis hormones, and inflammation cytokines in hyperalgesia and depression comorbidities. The reserpine-induced "Sprague Dawley" (SD) rat models were used, and the concentrations of monoamine neurotransmitters serotonin (5-HT), norepinephrine (NE), dopamine (DA), and their metabolic products 5-hydroxyindoleacetic acid (5-HIAA), Homovanillic acid (HVA), 3,4-Dihydroxyphenylacetic acid (DOPAC) in raphe nucleus region were tested by High Performance Liquid Chromatography (HPLC). Serum levels of Adrenocorticotropic Hormone (ACTH), Cortisol (CORT), and inflammatory cytokines interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, IL-4, IL-10 were assessed by enzyme linked immunosorbent assay.Repeated reserpine injection induced hyperalgesia and depressive behaviors with decreased sucrose preference and horizontal movement distance, and increased immobility time in forced swimming test. The concentrations of 5-HT and NE in raphe nucleus, and ACTH and CORT in serum were elevated in the model group. And the model group showed increases in serum IL-1β and IL-6, and decrease in serum IL-10.More research in these areas is needed to understand the pathogenesis of the disease, so as to find more and better therapeutic targets.© 2022. The Author(s).

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中科院(CAS)分区：

出版当年[2021]版：

大类 | 2 区医学

小类 | 3 区精神病学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区精神病学

JCR分区：

出版当年[2020]版：

Q2 PSYCHIATRY

最新[2023]版：

Q2 PSYCHIATRY

影响因子： 最新[2023版] 3.4 最新五年平均[2021-2025] 4.2 出版当年[2020版] 3.63 出版当年五年平均[2016-2020] 4.514 出版前一年[2019版] 2.704 出版后一年[2021版] 4.144

第一作者：

第一作者单位： [1]Department of Traditional Chinese Medicine, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong-an Road, Beijing, 100050, China. [2]Department of Integrated Traditional and Western Medicine, Capital Medical University, Beijing, 100050, China.

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