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Tumor endothelial cell-derived extracellular vesicles contribute to tumor microenvironment remodeling.

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单位： [1]Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, 110122, China. [2]Science Experiment Center of China Medical University, Shenyang, 110122, China. [3]Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100000, China. [4]National Clinical Research Center for Digestive Diseases, Beijing, 100000, China. [5]Department of General Surgery, Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121000, China. [6]Department of Radiotherapy, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121000, China. ly135722507hld@126.com. [7]Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, 110122, China. qqzheng@cmu.edu.cn.

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Cancer progression involves several biological steps where angiogenesis is a key tumorigenic phenomenon. Extracellular vesicles (EVs) derived from tumor cells and other cells in the tumor microenvironment (TME) help modulate and maintain favorable microenvironments for tumors. Endothelial cells (ECs) activated by cancer-derived EVs have important roles in tumor angiogenesis. Interestingly, EVs from ECs activate tumor cells, i.e. extracellular matrix (ECM) remodeling and provide more supplements for tumor cells. Thus, EV communications between cancer cells and ECs may be effective therapeutic targets for controlling cancer progression. In this review, we describe the current knowledge on EVs derived from ECs and we examine how these EVs affect TME remodeling. Video abstract.© 2022. The Author(s).

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第一作者单位： [1]Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, 110122, China. [2]Science Experiment Center of China Medical University, Shenyang, 110122, China.

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