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Single-Cell Transcriptional Analysis Deciphers the Inflammatory Response of Skin-Resident Stromal Cells

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收录情况: ◇ SCIE

单位: [1]Department of Dermatology, China–Japan Friendship Hospital, Beijing, China, [2]Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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关键词: scRNA-seq skin resident cells skin stromal cells immunoregulatory axis cellular communication

摘要:
The skin is the outermost barrier of the body. It has developed a sophisticated system against the ever-changing environment. The application of single-cell technologies has revolutionized dermatology research and unraveled the changes and interactions across skin resident cells in the healthy and inflamed skin. Single-cell technologies have revealed the critical roles of stromal cells in an inflammatory response and explained a series of plausible previous findings concerning skin immunity. Here, we summarized the functional diversity of skin stromal cells defined by single-cell analyses and how these cells orchestrated events leading to inflammatory diseases, including atopic dermatitis, psoriasis, vitiligo, and systemic lupus erythematosus.

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出版当年[2021]版:
大类 | 3 区 医学
小类 | 3 区 外科
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 外科
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出版当年[2020]版:
Q2 SURGERY
最新[2023]版:
Q2 SURGERY

影响因子: 最新[2023版] 最新五年平均[2021-2025] 出版当年[2020版] 出版当年五年平均[2016-2020] 出版前一年[2019版] 出版后一年[2021版]

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第一作者单位: [1]Department of Dermatology, China–Japan Friendship Hospital, Beijing, China, [2]Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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通讯机构: [1]Department of Dermatology, China–Japan Friendship Hospital, Beijing, China, [2]Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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