Coexistence of Primary Sjogren's Syndrome and Autoimmune Gastritis With Pernicious Anemia and Subacute Combined Degeneration of the Spinal Cord: Case Report and Literature Review
单位：[1]Department of Gastroenterology, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China,临床科室国家中心消化分中心消化内科首都医科大学附属北京友谊医院[2]Department of Critical Liver Diseases, Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China,临床科室国家中心肝病分中心首都医科大学附属北京友谊医院[3]Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Clinical Diagnosis, Treatment and Research Center of Pediatric Liver Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, China,临床科室国家中心普外分中心普外四科（肝脏移植外科）首都医科大学附属北京友谊医院[4]Clinical Center for Pediatric Liver Transplantation, Capital Medical University, Beijing, China,[5]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China,临床科室神经内科神经内科首都医科大学附属北京友谊医院[6]Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing, China医技科室病理科病理科首都医科大学附属北京友谊医院
BackgroundAutoimmune gastritis (AIG) and Primary Sjogren's syndrome (pSS) are both autoimmune diseases with low prevalence in China. Subacute combined degeneration (SCD) of the spinal cord is the most common neurological manifestation of vitamin B12 deficiency. Until now, a patient with pSS and complications of AIG including SCD has not been reported. Case PresentationA 69-year-old woman presented with palpitations and symmetrical and progressive numbness in her hands and feet. The patient had a sense of stepping on cotton and could not write or walk without help. We reviewed the patient's history and analyzed her blood tests, imaging, gastroscopic findings, and pathological results. The patient fulfilled the criteria of AIG, pSS, spinal cord SCD and early pernicious anemia (PA) simultaneously. Although pSS can lead to reduction of vitamin B12, this is the first overlapping case of pSS with spinal cord SCD. After symptomatic treatment, the patient returned to a normal life. ConclusionsThis first report about the coexistence of pSS and complications of AIG including SCD and PA will promote a better understanding of the relationship between these diseases.
基金：
This work was supported by Beijing Science and Technology
Planning Project (Z201100005620001).
第一作者单位：[1]Department of Gastroenterology, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China,[2]Department of Critical Liver Diseases, Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China,[3]Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Clinical Diagnosis, Treatment and Research Center of Pediatric Liver Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, China,[4]Clinical Center for Pediatric Liver Transplantation, Capital Medical University, Beijing, China,
通讯作者：
推荐引用方式(GB/T 7714)：
Zhan Hao-Su,Yao Xin,Hu Hai-Yi,et al.Coexistence of Primary Sjogren's Syndrome and Autoimmune Gastritis With Pernicious Anemia and Subacute Combined Degeneration of the Spinal Cord: Case Report and Literature Review[J].FRONTIERS in IMMUNOLOGY.2022,13:doi:10.3389/fimmu.2022.908528.
APA：
Zhan, Hao-Su,Yao, Xin,Hu, Hai-Yi,Han, Yan-Fei,Yue, Bing...&Wang, Yong-Jun.(2022).Coexistence of Primary Sjogren's Syndrome and Autoimmune Gastritis With Pernicious Anemia and Subacute Combined Degeneration of the Spinal Cord: Case Report and Literature Review.FRONTIERS in IMMUNOLOGY,13,
MLA：
Zhan, Hao-Su,et al."Coexistence of Primary Sjogren's Syndrome and Autoimmune Gastritis With Pernicious Anemia and Subacute Combined Degeneration of the Spinal Cord: Case Report and Literature Review".FRONTIERS in IMMUNOLOGY 13.(2022)
医学