单位：[1]State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Advanced Functional Polymer Composites, Beijing University of Chemical Technology, 100029 Beijing, China.[2]Dental Medical Center, China-Japan Friendship Hospital, Beijing 100029, China[3]Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China[4]College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, China.
Drug-derived carbon dots (CDs) not only have excellent photoluminescence properties of CDs, but also maintain pharmacological effects of original drugs, so as to realize extended applications for both bioimaging and chemotherapy. In this work, metformin (Met)-derived CDs (Met-CDs) as multifunctional nanocarriers with tumor cell imaging and cancer therapy are synthesized using Met and citric acid as precursors. The created Met-CDs exhibit obvious resistance to photobleaching, significant pH sensitivity in acidic environments, good pH stability in alkaline environments, and high temperature sensitivity. In addition, we further investigate the biological activity of Met-CDs using diabetic cell models, which demonstrate the ability of Met-CDs to treat diabetes and reduce the production of reactive oxygen species in diseased cells. Subsequently, human alveolar adenocarcinoma basal epithelial cells (A549) are cultured in both normal glucose and low glucose media, and different concentrations of Met and Met-CDs are added to investigate the effect of Met-CDs on A549 cells. Finally, we successfully utilize the prepared Met-CDs to image live A549 cells in vitro in normal glucose medium. The Met-CDs prepared in this work reveal high potential to be used as both fluorescent probes and drug agents for tumor therapy, realizing controllable integrated diagnosis and treatment of diseases.
基金：
The authors acknowledge the financial support from the
National Natural Science Foundation of China (NSFC, Grant
No. 51873016 and 51873225), the Joint Project of BRC-BC
(Biomedical Translational Engineering Research Center of
BUCT-CJFH (XK2020-11) and the Research Project of China-
Japan Friendship Hospital (No. 2019-2-QN-86).
第一作者单位：[1]State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Advanced Functional Polymer Composites, Beijing University of Chemical Technology, 100029 Beijing, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Wan Jiafeng,Xu Shiqing,Li Jing,et al.Facile synthesis of multifunctional pharmaceutical carbon dots for targeted bioimaging and chemotherapy of tumors[J].NANOSCALE.2022,doi:10.1039/d2nr03321f.
APA：
Wan, Jiafeng,Xu, Shiqing,Li, Jing,Yu, Mengliu,Zhang, Kai...&Su, Zhiqiang.(2022).Facile synthesis of multifunctional pharmaceutical carbon dots for targeted bioimaging and chemotherapy of tumors.NANOSCALE,,
MLA：
Wan, Jiafeng,et al."Facile synthesis of multifunctional pharmaceutical carbon dots for targeted bioimaging and chemotherapy of tumors".NANOSCALE .(2022)
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