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Asia-Pacific Colorectal Screening Score Combined with Stool DNA Test Improves the Detection Rate for Colorectal Advanced Neoplasms

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资源类型：
Pubmed体系：
作者：
Xu Junfeng[1] * ; Rong Long[2] ; Gu Fang[3] ; You Peng[4] ; Ding Hui[5] ; Zhai Huihong[6] ; Wang Bangmao[7] ; Li Yanqing[8] ; Ma Xianzong[9,10] ; Yin Fumei[9,10] ; Yang Lang[1,10] ; He Yuqi[10] ; Sheng Jianqiu[1,10] ; Jin Peng[1,10,*1] ;
单位： [1]Senior Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, China [2]Department of Endoscopy Center, Peking University First Hospital, Beijing, China [3]Department of Gastroenterology, Peking University Third Hospital, Beijing, China [4]Department of Gastroenterology, Peking University People’s Hospital, Beijing, China [5]Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China [6]National Clinical Research Center for Digestive Diseases, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, China [7]Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, China [8]Department of Gastroenterology, Shandong University Qilu Hospital, Jinan, China [9]Chinese PLA General Hospital, Beijing, China [10]Department of Gastroenterology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China
出处：
DOI： 10.1016/j.cgh.2022.09.002
ISSN：

摘要：
The Asia-Pacific Colorectal Screening (APCS) scoring system was developed to stratify the risk of colorectal advanced neoplasm (AN). We aimed to evaluate the performance of the APCS score combined with a stool DNA test used for colorectal cancer screening.A total of 2,842 subjects who visited outpatient clinics or cancer screening centers were enrolled. Age, sex, smoking status, and family history were recorded and APCS scores were calculated in 2,439 participants. Stool DNA test (SDC2 and SFRP2 tests) and fecal immunochemical test (FIT) were performed and colonoscopy was used as the gold standard among 2,240 subjects who completed all study procedures. We utilized a threshold of 4.4 μg/gm for the FIT, in addition to the manufacturer's recommended threshold of 20 μg/gm to match the specificity of a stool DNA test.Based on the APCS score, 38.8% (946/2439) of the subjects were categorized as high risk, and they had a 1.8-fold increase in risk for AN (95% CI 1.4-2.3) compared to low and moderate risk. The APCS combined with the stool DNA test detected 95.2% of invasive cancers (40/42) and 73.5% of ANs (253/344), while the colonoscopy workload was only 47.1% (1056/2240). The sensitivity for AN of APCS combined with stool DNA test was significantly higher than that of APCS combined with FIT (73.5% vs 62.8% with FIT cutoff=20 μg/gm, 73.5% vs 68.0% with FIT cutoff=4.4 μg/gm, both p<0.01).The APCS score combined with a stool DNA test significantly improved the detection of advanced colorectal advanced neoplasms, while limiting colonoscopy resource utilization. (Chictr.org.cn, ChiCTR-DDD-17011169).Copyright © 2022 AGA Institute. Published by Elsevier Inc. All rights reserved.

基金：
This work was supported by grants from the Beijing Municipal Science and Technology Commission (D171100002617001).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 1 区 医学
小类 | 1 区 胃肠肝病学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 胃肠肝病学
JCR分区：
出版当年[2020]版：
Q1 GASTROENTEROLOGY & HEPATOLOGY
最新[2023]版：
Q1 GASTROENTEROLOGY & HEPATOLOGY

影响因子： 最新[2023版] 最新五年平均[2021-2025] 出版当年[2020版] 出版当年五年平均[2016-2020] 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者单位： [1]Senior Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, China
通讯作者：
通讯机构： [1]Senior Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, China [10]Department of Gastroenterology, The Seventh Medical Center of Chinese PLA General Hospital, Beijing, China [*1]Senior Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing, 100853 China.
推荐引用方式(GB/T 7714)：
Xu Junfeng,Rong Long,Gu Fang,et al.Asia-Pacific Colorectal Screening Score Combined with Stool DNA Test Improves the Detection Rate for Colorectal Advanced Neoplasms[J].Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association.2022,doi:10.1016/j.cgh.2022.09.002.
APA：
Xu Junfeng,Rong Long,Gu Fang,You Peng,Ding Hui...&Jin Peng.(2022).Asia-Pacific Colorectal Screening Score Combined with Stool DNA Test Improves the Detection Rate for Colorectal Advanced Neoplasms.Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association,,
MLA：
Xu Junfeng,et al."Asia-Pacific Colorectal Screening Score Combined with Stool DNA Test Improves the Detection Rate for Colorectal Advanced Neoplasms".Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association .(2022)

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