单位：[1]Shandong First Med Univ, Dept Resp & Crit Care Med, Shandong Prov Hosp, Jinan, Shandong, Peoples R China[2]Shandong Key Lab Infect Resp Dis, Jinan, Shandong, Peoples R China[3]Chinese Acad Med Sci, Inst Resp Med, Peking Union Med Coll, Beijing, Peoples R China[4]China Japan Friendship Hosp, Dept Pulm & Crit Care Med, Ctr Resp Dis, Beijing, Peoples R China[5]Shandong Ctr Dis Control & Prevent, Jinan, Shandong, Peoples R China[6]Tsinghua Univ, Tsinghua Univ Peking Univ Joint Ctr Life Sci, Beijing, Peoples R China
Background T cell lymphopenia was a significant characteristic of severe influenza infection and it was associated with the functional changes of T cells. It is necessary to clarify the T cells characteristics of kinetic changes and their correlation with disease severity. Methods In a cohort of hospitalized influenza patients with varying degrees of severity, we characterized lymphocyte populations using flow cytometry. Results The numbers of cycling (Ki67(+)) T cells at the acute phase of severe influenza were higher, especially in the memory (CD45RO(+)) T cell subsets. T cells from hospitalized influenza patients also had significantly higher levels of the exhausted marker PD-1. Cycling status of T cells was associated with T cell activation during the acute phase of influenza infection. The recruitment of cycling and activated (CD38(+)HLA-DR+) CD8(+) T cells subset is delayed in severe influenza patients. Conclusions The increased numbers of cycling memory (Ki67(+)CD45RO(+)) T cells subsets and delayed kinetics of activated (CD38(+)HLA-DR+) CD8(+) T cells, could serve as possible biological markers for disease severity.
基金：
Natural Science Foundation of China [81970010/H0104, 82030002/H0102]; Research incubation Foundation of Shandong Provincial Hospital Affiliated to Shandong First Medical University [2021FY028]
第一作者单位：[1]Shandong First Med Univ, Dept Resp & Crit Care Med, Shandong Prov Hosp, Jinan, Shandong, Peoples R China[2]Shandong Key Lab Infect Resp Dis, Jinan, Shandong, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[3]Chinese Acad Med Sci, Inst Resp Med, Peking Union Med Coll, Beijing, Peoples R China[4]China Japan Friendship Hosp, Dept Pulm & Crit Care Med, Ctr Resp Dis, Beijing, Peoples R China[6]Tsinghua Univ, Tsinghua Univ Peking Univ Joint Ctr Life Sci, Beijing, Peoples R China
推荐引用方式(GB/T 7714)：
Liu Shuai,Huang Zhisheng,Fan Ruyue,et al.Cycling and activated CD8(+) T lymphocytes and their association with disease severity in influenza patients[J].BMC IMMUNOLOGY.2022,23(1):doi:10.1186/s12865-022-00516-1.
APA：
Liu, Shuai,Huang, Zhisheng,Fan, Ruyue,Jia, Ju,Deng, Xiaoyan...&Cao, Bin.(2022).Cycling and activated CD8(+) T lymphocytes and their association with disease severity in influenza patients.BMC IMMUNOLOGY,23,(1)
MLA：
Liu, Shuai,et al."Cycling and activated CD8(+) T lymphocytes and their association with disease severity in influenza patients".BMC IMMUNOLOGY 23..1(2022)
