单位：[1]Xiyuan hospital of China Academy of Chinese Medical Sciences, Beijing, China,[2]National ClinicalResearch Centre for Chinese Medicine Cardiology, Xiyuan Hospital of China Academy of ChineseMedical Sciences, Beijing, China,[3]Graduate School of Beijing University of Chinese Medicine,Beijing, China,[4]Gynecological Department of Traditional Chinese Medicine, China-JapanFriendship Hospital, Beijing, China
Protein kinase C (PKC) is a family of serine/threonine protein kinases, the activation of which plays an important role in the development of diabetic microvascular complications. The activation of PKC under high-glucose conditions stimulates redox reactions and leads to an accumulation of redox stress. As a result, various types of cells in the microvasculature are influenced, leading to changes in blood flow, microvascular permeability, extracellular matrix accumulation, basement thickening and angiogenesis. Structural and functional disorders further exacerbate diabetic microvascular complications. Here, we review the roles of PKC in the development of diabetic microvascular complications, presenting evidence from experiments and clinical trials.
基金：
National Natural
Science Foundation of China (Grant number: 81904025,
82104907) and Fundamental Research Funds for the Central
public welfare research institutes Grant (Grant number: ZZ13-
YQ-016 and ZZ13-YQ-016-C1).
第一作者单位：[1]Xiyuan hospital of China Academy of Chinese Medical Sciences, Beijing, China,[2]National ClinicalResearch Centre for Chinese Medicine Cardiology, Xiyuan Hospital of China Academy of ChineseMedical Sciences, Beijing, China,[3]Graduate School of Beijing University of Chinese Medicine,Beijing, China,
共同第一作者：
通讯作者：
通讯机构：[1]Xiyuan hospital of China Academy of Chinese Medical Sciences, Beijing, China,[2]National ClinicalResearch Centre for Chinese Medicine Cardiology, Xiyuan Hospital of China Academy of ChineseMedical Sciences, Beijing, China,
推荐引用方式(GB/T 7714)：
Pan Deng,Xu Lin,Guo Ming.The role of protein kinase C in diabetic microvascular complications[J].FRONTIERS IN ENDOCRINOLOGY.2022,13:doi:10.3389/fendo.2022.973058.
APA：
Pan, Deng,Xu, Lin&Guo, Ming.(2022).The role of protein kinase C in diabetic microvascular complications.FRONTIERS IN ENDOCRINOLOGY,13,
MLA：
Pan, Deng,et al."The role of protein kinase C in diabetic microvascular complications".FRONTIERS IN ENDOCRINOLOGY 13.(2022)
