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Association between hemoglobin level and cognitive profile in old adults: A cross-sectional survey

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单位: [1]Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China. [2]Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China. [3]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, China. [4]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. [5]Department of Neurology, Fuxing Hospital, Capital Medical University, Beijing, China. [6]School of Nursing, Tianjin Medical University, Tianjin, China. [7]Department of Neurology, Tianjin Key Laboratory of Cerebrovascular and of Neurodegenerative Diseases, Tianjin Dementia Institute, Tianjin Huanhu Hospital, Tianjin, China.
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In the present study, the association between Hemoglobin (HGB) level and cognitive profile was investigated and whether it affected the dementia risk in older adults.A cross-sectional population-based survey that included 3519 individuals ≥65 years of age was conducted in 2019. Basic demographic characteristics were collected. The neuropsychological assessments and blood tests were administered to evaluate cognition and HGB level. Generalized additive models were used to analyze the non-linear association between HGB levels and cognitive function. Logistics regression models were utilized to analyze the associations between HGB level and dementia risk.Overall, 459 (12.7%) participants were diagnosed with dementia and there were more females (54.7%) than males (45.3%). The number of subjects with anemia (3%) or hyperhemoglobinemia (5.2%) was higher than participants with normal HGB level. A visual representation of the relationship between HGB level and Mini-Mental State Examination (MMSE) score showed an inverted U-curve, which is more evident in female. Logistics regression models showed that anemia (odds ratio, OR = 1.826, 95% confidence interval, CI: 1.166-2.860, p < 0.01), but not hyperhemoglobinemia, significantly increased the risk of dementia. These trends were not the same for males and females. An abnormal HGB level had greater effects in females, resulting in higher risk of dementia for females with anemia or hyperhemoglobinemia than subjects with normal HGB level including males.Both low and high HGB levels can lead to cognitive decline in the incidence of dementia, indicating an inverted U-shaped curve association may exist between HGB level and global cognitive profile.© 2022 John Wiley & Sons Ltd.

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出版当年[2021]版:
大类 | 2 区 医学
小类 | 3 区 老年医学 3 区 精神病学 3 区 老年医学
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 老年医学 3 区 老年医学(社科) 3 区 精神病学
JCR分区:
出版当年[2020]版:
Q1 GERONTOLOGY Q2 PSYCHIATRY Q3 GERIATRICS & GERONTOLOGY
最新[2024]版:
Q1 GERONTOLOGY Q2 PSYCHIATRY Q3 GERIATRICS & GERONTOLOGY

影响因子: 最新[2024版] 最新五年平均[2021-2025] 出版当年[2020版] 出版当年五年平均[2016-2020] 出版前一年[2019版] 出版后一年[2021版]

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第一作者单位: [1]Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.
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通讯机构: [2]Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China. [7]Department of Neurology, Tianjin Key Laboratory of Cerebrovascular and of Neurodegenerative Diseases, Tianjin Dementia Institute, Tianjin Huanhu Hospital, Tianjin, China.
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