The Chronic Kidney Disease Epidemiology Collaboration equations perform less well in an older population with type 2 diabetes than their non-diabetic counterparts
单位：[1]China Japan Friendship Hosp, Dept Nephrol, Beijing, Peoples R China[2]Peking Union Med Coll & Chinese Acad Med Sci, Grad Sch Peking Union Med Coll, Beijing, Peoples R China
Objectives: The Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) equations are based on creatinine alone (CKD-EPIcr), cystatin C alone (CKD-EPIcys) and combined creatinine and cystatin C (CKD-EPIcr-cys). It remains unclear whether these equations perform di erently in older adults with type 2 diabetes than they do in non-diabetic older individuals. Methods: This single-center cross-sectional study was performed in adults aged >= 65 years between January 2019 and December 2021. Glomerular filtration rate (GFR) was measured by technetium-99m-diethylene triamine pentaacetic acid (Tc-99m -DTPA) renal dynamic imaging. The bias (di erence between measured and estimated GFR), precision [interquartile range (IQR) of the median di erence between measured GFR and estimated GFR] and accuracy P30 (percentage of estimated GFR within 30% ofmeasured GFR) were considered the criteria of equation performance. Results: Finally, 476 participants were enrolled, including 243 adults with type 2 diabetes and 233 non-diabetic adults. The mean age of the included participants was 71.69 +/- 6.4 years and 262 (55%) were male. The mean measured GFR was 49.02 +/- 22.45 ml/min/1.73 m(2). The CKD-EPIcr-cys equation showed significantly greater bias and lower accuracy (P30) in individuals with diabetes than in the non-diabetic group (median bias, 4.08 vs. 0.41 ml/min/1.73 m(2), respectively, p < 0.05; P30, 63.78% vs. 78.54%, respectively, p < 0.05). The precision IQR indicated that CKD-EPIcr-cys had also lower precision in individuals with diabetes than in the non-diabetic controls (17.27 vs. 15.49 ml/min/1.73 m(2), respectively). Similar results were observed for CKD-EPIcr and CKD-EPIcys equations. The P30 of all three equations failed to reach 80% in diabetic and non-diabetic groups. Conclusions: The performance of the CKD-EPI equations was lower in a group of patients aged >= 65 years with type 2 diabetes than in non-diabetic counterparts. However, each equation still had limitations regarding accuracy in older adults with or without diabetes.
基金：
Science and Technology Project of Beijing [D171100002817002]; National Key Clinical Specialty Capacity Building Project [2019-542]; National Key R&D Program of China [2018YFC1704304]
语种：
外文
WOS：
中科院(CAS)分区：
出版当年[2021]版：
大类|3 区医学
小类|3 区公共卫生、环境卫生与职业卫生
最新[2025]版：
大类|3 区医学
小类|3 区公共卫生、环境卫生与职业卫生
JCR分区：
出版当年[2020]版：
Q1PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTHQ2PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
第一作者单位：[1]China Japan Friendship Hosp, Dept Nephrol, Beijing, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Jiang Shimin,Zhang Danyang,Li Wenge.The Chronic Kidney Disease Epidemiology Collaboration equations perform less well in an older population with type 2 diabetes than their non-diabetic counterparts[J].FRONTIERS IN PUBLIC HEALTH.2022,10:doi:10.3389/fpubh.2022.952899.
APA：
Jiang, Shimin,Zhang, Danyang&Li, Wenge.(2022).The Chronic Kidney Disease Epidemiology Collaboration equations perform less well in an older population with type 2 diabetes than their non-diabetic counterparts.FRONTIERS IN PUBLIC HEALTH,10,
MLA：
Jiang, Shimin,et al."The Chronic Kidney Disease Epidemiology Collaboration equations perform less well in an older population with type 2 diabetes than their non-diabetic counterparts".FRONTIERS IN PUBLIC HEALTH 10.(2022)
