Purpose of review This review provides updates regarding biomarker studies that address key clinical unmet needs, which relate to the evaluation of the disease activity in patients with dermatomyositis. Recent findings Increasing evidence supports that the serum levels of dermatomyositis-specific antibodies (DM-MSAs), which include anti-Mi-2, anti-NXP2, anti-MDA5, anti-TNF1-gamma, and anti-SAE, are correlated with the disease activity. Moreover, serial measurements of DM-MSA levels may help to predict the disease status. Beyond the MSA, macrophage activation-related biomarker-soluble CD163, CD206, neopterin, and galectin-3/9 are the most currently talked biomarkers for disease activity in dermatomyositis; new circulating T-cell subsets CD4+CXCR5+CCR7 loPD-1hi and TIGIT+CD226+ CD4 T cells can potentially harbor biomarkers of disease activity in dermatomyositis. In addition, LDGs and NETs were also shown to be correlated with the disease activities of dermatomyositis. Summary Promising candidate biomarkers are now available for evaluating disease activity in dermatomyositis. These biomarkers need external validation in other large cohort studies.
基金：
National High Level Hospital Clinical Research Funding [2022-NHLHCRF-YS-02]; National Natural Science Foundation of China [81971531, 82171788]; Elite Medical Professionals project of China-Japan Friendship Hospital [ZRJY2021-GG13]
第一作者单位：[1]China Japan Friendship Hosp, Dept Rheumatol, Key Lab Myositis, 2 Yinhua St, Beijing 100029, Peoples R China
通讯作者：
通讯机构：[1]China Japan Friendship Hosp, Dept Rheumatol, Key Lab Myositis, 2 Yinhua St, Beijing 100029, Peoples R China[*1]Department of Rheumatology, Key Laboratory of Myositis, China-Japan Friendship Hospital, No. 2, Yinhua Street, Chaoyang District, Beijing 100029, China
推荐引用方式(GB/T 7714)：
Lu Xin,Peng Qinglin,Wang Guochun.Biomarkers of disease activity in dermatomyositis[J].CURRENT OPINION IN RHEUMATOLOGY.2022,34(6):289-294.doi:10.1097/BOR.0000000000000905.
APA：
Lu, Xin,Peng, Qinglin&Wang, Guochun.(2022).Biomarkers of disease activity in dermatomyositis.CURRENT OPINION IN RHEUMATOLOGY,34,(6)
MLA：
Lu, Xin,et al."Biomarkers of disease activity in dermatomyositis".CURRENT OPINION IN RHEUMATOLOGY 34..6(2022):289-294
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