单位：[1]Beijing Friendship Hospital, Capital Medical University, 100050 Beijing, China首都医科大学附属北京友谊医院[2]Sanbo Brain Hospital, Capital Medical University, 100093 Beijing, China[3]The Sixth Medical Center of PLA General Hospital, 100142 Beijing, China[4]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 100070 Beijing, China首都医科大学附属天坛医院[5]Department of Neurology, The Fourth Hospital of Harbin Medical University, 150081 Harbin, China[6]National Clinical Research Center for Neurological Diseases, 100070 Beijing, China[7]Advanced Innovation Center for Human Brain Protection, Capital Medical University, 100070 Beijing, China[8]Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, 100069 Beijing, China
Stroke is one of the leading causes of death and long-term serious disability. Current therapeutic strategy is limited to thrombolytic agents, consequently, boosting endogenous neuroprotective mechanisms of the brain to protect itself against harmful stimuli and restore from damages are widely studied. Preconditioned brain to tolerate cerebral ischemia/reperfusion injury could be initiated by several different pharmacological and mechanical strategies, such as ischemic preconditioning, ethanol pharmacological preconditioning and other pre- and post-conditions, such as remote ischemic preconditioning and exercise preconditioning. In this article, we will discuss the major mechanism of ischemia/reperfusion injury and provide an overview of preconditioning in all its various forms, describe the underlying mechanisms and review the recent clinical application of this emerging neuroprotective strategy.
基金：
National Key R&D Program of China [2017YFC1307500]; Capital Health Research and Development of Special grants [2020-1-2013]; Beijing-Tianjin-Hebei Cooperative Basic Research Program [H2018206435]; Beijing Postdoctoral Research Foundation [ZZ2020-06]; Beijing Natural Science Foundation [Z200024]
第一作者单位：[1]Beijing Friendship Hospital, Capital Medical University, 100050 Beijing, China[2]Sanbo Brain Hospital, Capital Medical University, 100093 Beijing, China[4]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 100070 Beijing, China[6]National Clinical Research Center for Neurological Diseases, 100070 Beijing, China[7]Advanced Innovation Center for Human Brain Protection, Capital Medical University, 100070 Beijing, China
共同第一作者：
通讯作者：
通讯机构：[4]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 100070 Beijing, China[6]National Clinical Research Center for Neurological Diseases, 100070 Beijing, China[8]Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, 100069 Beijing, China
推荐引用方式(GB/T 7714)：
Yang Huajun,Qi Chengxuan,Su Fang,et al.Cerebral Ischemia/Reperfusion Injury and Pharmacologic Preconditioning as a Means to Reduce Stroke-induced Inflammation and Damage[J].NEUROCHEMICAL RESEARCH.2022,doi:10.1007/s11064-022-03789-5.
APA：
Yang, Huajun,Qi, Chengxuan,Su, Fang,Shan, Wei,Guo, Anchen...&Wang, Qun.(2022).Cerebral Ischemia/Reperfusion Injury and Pharmacologic Preconditioning as a Means to Reduce Stroke-induced Inflammation and Damage.NEUROCHEMICAL RESEARCH,,
MLA：
Yang, Huajun,et al."Cerebral Ischemia/Reperfusion Injury and Pharmacologic Preconditioning as a Means to Reduce Stroke-induced Inflammation and Damage".NEUROCHEMICAL RESEARCH .(2022)
