Long-term influence of type 2 diabetes and metabolic syndrome on all-cause and cardiovascular death, and microvascular and macrovascular complications in Chinese adults-A 30-year follow-up of the Da Qing diabetes study
单位：[1]Chinese Acad Med Sci & Peking Union Med Coll, Endocrinol Ctr, Fuwai Hosp, Beijing, Peoples R China[2]Da Qing First Hosp, Dept Cardiol, Da Qing, Peoples R China[3]Harbin Med Univ, Dept Endocrinol, Affiliated Hosp 4, Harbin, Peoples R China[4]Chinese Ctr Dis Control & Prevent, Div Noncommunicable Dis Control & Community Hlth, Beijing, Peoples R China[5]China Japan Friendship Hosp, Beijing, Peoples R China[6]Univ Alabama Birmingham, Diabet Res & Training Ctr, Birmingham, AL 35233 USA
Aims: To examine the long-term influence of metabolic syndrome (MetS) on death and vascular complications. Methods: Altogether, 1419 individuals with different levels of glycemia and MetS were recruited for this study. The participants were followed up for 30 years to assess outcomes. Results: Compared with the non_MetS, individuals with impaired glucose tolerance (IGT) plus MetS had a higher incidence (per 1000 person-years) of all-cause death (20.98 vs 11.70, hazard ratio [HR] = 1.84), macrovascular events (29.25 vs 15.94, HR = 1.36), and microvascular complications (10.66 vs 3.57, HR = 1.96). The incidence of these outcomes was even higher in participants with type 2 diabetes mellitus (T2DM) plus MetS. The T2DM without MetS shared a comparable risk profile of the outcomes with the T2DM plus MetS group (HRs were 3.45 vs 3.15, 2.21 vs 2.65, and 6.91 vs 7.41, respectively). Conclusions: The degree of hyperglycemia in MetS is associated with the severity of death and both micro- and macrovascular complications. T2DM was associated with a comparable risk for all outcomes as T2DM plus MetS. The findings highlight the need of early prevention of diabetes in individuals with IGT plus MetS, while the justification to redefine a subgroup of patients with T2DM as having MetS remains to be clarified.
基金：
World Bank; Ministry of Public Health of the People's Republic of China; Da Qing First Hospital; US Centers for Disease Control and Prevention (CDC)-WHO; China-Japan Friendship Hospital [U58/CCU424123-01-02)]; US CDC-Chinese Center for Disease Control and Prevention; [5U19GH000636-05]
第一作者单位：[1]Chinese Acad Med Sci & Peking Union Med Coll, Endocrinol Ctr, Fuwai Hosp, Beijing, Peoples R China
通讯作者：
通讯机构：[1]Chinese Acad Med Sci & Peking Union Med Coll, Endocrinol Ctr, Fuwai Hosp, Beijing, Peoples R China[5]China Japan Friendship Hosp, Beijing, Peoples R China
推荐引用方式(GB/T 7714)：
He Siyao,Wang Jinping,Zhang Xiaoxing,et al.Long-term influence of type 2 diabetes and metabolic syndrome on all-cause and cardiovascular death, and microvascular and macrovascular complications in Chinese adults-A 30-year follow-up of the Da Qing diabetes study[J].DIABETES RESEARCH AND CLINICAL PRACTICE.2022,191:doi:10.1016/j.diabres.2022.110048.
APA：
He, Siyao,Wang, Jinping,Zhang, Xiaoxing,Qian, Xin,Yan, Shuang...&Li, Guangwei.(2022).Long-term influence of type 2 diabetes and metabolic syndrome on all-cause and cardiovascular death, and microvascular and macrovascular complications in Chinese adults-A 30-year follow-up of the Da Qing diabetes study.DIABETES RESEARCH AND CLINICAL PRACTICE,191,
MLA：
He, Siyao,et al."Long-term influence of type 2 diabetes and metabolic syndrome on all-cause and cardiovascular death, and microvascular and macrovascular complications in Chinese adults-A 30-year follow-up of the Da Qing diabetes study".DIABETES RESEARCH AND CLINICAL PRACTICE 191.(2022)
