The purpose of the study was to build an AI model with selected preoperative clinical features to further improve the accuracy of the assessment of benign and malignant breast nodules.Patients who underwent ultrasound, strain elastography, and S-Detect before ultrasound-guided biopsy or surgical excision were enrolled. The diagnosis model was built using a logistic regression model. The diagnostic performances of different models were evaluated and compared.A total of 179 lesions (101 benign and 78 malignant) were included. The whole dataset consisted of a training set (145 patients) and an independent test set (34 patients). The AI models constructed based on clinical features, ultrasound features, and strain elastography to predict and classify benign and malignant breast nodules had ROC AUCs of 0.87, 0.81, and 0.79 in the test set. The AUCs of the sonographer and S-Detect were 0.75 and 0.82, respectively, in the test set. The AUC of the combined AI model with the best performance was 0.89 in the test set. The combined AI model showed a better specificity of 0.92 than the other models. The sonographer's assessment showed better sensitivity (0.97 in the test set).The combined AI model could improve the preoperative identification of benign and malignant breast masses and may reduce unnecessary breast biopsies.Copyright © 2022 Sun, Feng, Chen, Dekker, Qian, Wang and Guo.