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Circular RNAs: Emerging players in the pathogenesis of keloid

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收录情况： ◇ SCIE

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单位： [1]Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

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关键词： circular RNAs circRNAs keloid miRNA mRNA

摘要：

Circular RNAs (circRNAs) are a new type of non-coding RNAs originating from precursor messenger RNAs. Recent research has confirmed that circRNAs play a significant role in various biological and pathological processes, including cell viability, migration, and apoptosis. Emerging studies have demonstrated that the deregulated circRNA-miRNA-mRNA interaction network plays a key role in the development of many diseases. Increasing evidence has highlighted the role of ncRNAs (mainly miRNAs and lncRNAs) in the pathogenesis of keloids. Recently, several publications also indicated that circRNAs contribute to keloid development. The discovery of circRNAs changed the current understanding of the biology of keloids It is crucial to elucidate a circRNA-miRNA-mRNA network to understand the pathological mechanism of keloids. In the present review, we summarize the aberrant expression of regulatory roles of circRNAs in keloids. We discuss the potential clinical application of circRNAs in the diagnosis and treatment of keloids.Copyright © 2022 Yu, Zhu, Li and Gao.

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出版当年[2021]版：

大类 | 2 区

医学

小类 | 2 区生理学

最新[2025]版：

大类 | 3 区医学

小类 | 2 区生理学

JCR分区：

出版当年[2020]版：

Q1 PHYSIOLOGY

最新[2023]版：

Q2 PHYSIOLOGY

影响因子： 最新[2023版] 3.2 最新五年平均[2021-2025] 4 出版当年[2020版] 4.566 出版当年五年平均[2016-2020] 4.805 出版前一年[2019版] 3.367 出版后一年[2021版] 4.755

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第一作者单位： [1]Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

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