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A chromosome-encoded T4SS independently contributes to horizontal gene transfer in Enterococcus faecalis

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资源类型：
Pubmed体系：
作者：
Hua Mingxi[1,2,3] * ; Dai Dongfa[3] * ; Du Pengcheng[3] ; Chen Nan[3] ; Duan Ang[3] ; Yue Jinglin[1,2] ; Jia Hongbing[4] ; Rong Chengbo[1,2] ; Li Ang[3] ; Zeng Hui[1,2,3] ; Chen Chen[1,2,3] ;
单位： [1]Biomedical Innovation Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China [2]Beijing Key Laboratory for Therapeutic Cancer Vaccines, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China [3]Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China [4]Department of Clinical Laboratory, China-Japan Friendship Hospital, Beijing 100029, China
出处：
DOI： 10.1016/j.celrep.2022.111609

摘要：
Bacterial type IV secretion systems (T4SSs) are the specific devices that mediate the dissemination of antibiotic resistant genes via horizontal gene transfer (HGT). Multi-drug-resistant Enterococcus faecalis (E. faecalis) represents a clinical public health threat because of its transferable plasmid with a functional plasmid-encoded (PE)-T4SS. Here, we report a chromosome-encoded (CE)-T4SS that exists in 40% of E. faecalis isolates. Compared with the PE-T4SS, CE-T4SS displays distinct characteristics in protein architecture and is capable of mediating large and genome-wide gene transfer in an imprecise manner. Reciprocal exchange of CE-T4SS- or PE-T4SS-associated origin of transfer (oriT) could disrupt HGT function, indicating that CE-T4SS is an independent system compared with PE-T4SS. Taken together, the CE-T4SS sheds light on the knowledge of HGT in gram-positive bacteria and triggers us to explore more evolutionary mechanisms in E. faecalis.Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
最新[2025]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
JCR分区：
出版当年[2020]版：
Q1 CELL BIOLOGY
最新[2023]版：
Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均[2021-2025] 出版当年[2020版] 出版当年五年平均[2016-2020] 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者单位： [1]Biomedical Innovation Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China [2]Beijing Key Laboratory for Therapeutic Cancer Vaccines, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China [3]Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
共同第一作者：
通讯作者：
通讯机构： [1]Biomedical Innovation Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China [2]Beijing Key Laboratory for Therapeutic Cancer Vaccines, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China [3]Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
推荐引用方式(GB/T 7714)：
Hua Mingxi,Dai Dongfa,Du Pengcheng,et al.A chromosome-encoded T4SS independently contributes to horizontal gene transfer in Enterococcus faecalis[J].Cell Reports.2022,41(6):111609.doi:10.1016/j.celrep.2022.111609.
APA：
Hua Mingxi,Dai Dongfa,Du Pengcheng,Chen Nan,Duan Ang...&Chen Chen.(2022).A chromosome-encoded T4SS independently contributes to horizontal gene transfer in Enterococcus faecalis.Cell Reports,41,(6)
MLA：
Hua Mingxi,et al."A chromosome-encoded T4SS independently contributes to horizontal gene transfer in Enterococcus faecalis".Cell Reports 41..6(2022):111609

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