单位：[1]Capital Med Univ, Beijing Friendship Hosp, Dept Pediat, Beijing, Peoples R China临床科室儿科儿科首都医科大学附属北京友谊医院[2]Inner Mongolia Med Univ, Dept Neonatol, Affiliated Hosp, Hohhot, Peoples R China
Behavioral changes in newborn 3-day-old rats (n=44) with modeled hypoxic-ischemic brain injury (HIBI) were observed, and the expression of CDK8 in brain tissues was detected to clarify the significance of CDK8. In 30 min, 3 h, and 3 days after HIBI, the left (ischemic) hemisphere was taken for examination. In 3 days after HIBI, the rat pups were examined in the behavioral tests. In rat pups with HIBI, changes of CDK8 expression were detected by Western blotting and real-time PCR and changes in the righting reflex and forelimb grip strength test (p < 0.05) were revealed in comparison with sham-operated animals. The expression of CDK8 increased 30 min after HIBI and decreased in 3 h and 3 days. Hypoxia and ischemia of the left brain may affect locomotion, but not sensation. Since CDK8 is involved in the immune response after cerebral hypoxia and ischemia, this kinase can be used as an early diagnostic index.
第一作者单位：[1]Capital Med Univ, Beijing Friendship Hosp, Dept Pediat, Beijing, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Y.,Cui H.,Mei H.,et al.Effect of Hypoxic-Ischemic Brain Injury in Neonatal Rats on Behavioral Parameters and Expression of CDK8 in the Brain Tissue[J].BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE.2022,174(1):13-17.doi:10.1007/s10517-022-05638-5.
APA：
Zhang, Y.,Cui, H.,Mei, H.,Yang, L.&Xin, C..(2022).Effect of Hypoxic-Ischemic Brain Injury in Neonatal Rats on Behavioral Parameters and Expression of CDK8 in the Brain Tissue.BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE,174,(1)
MLA：
Zhang, Y.,et al."Effect of Hypoxic-Ischemic Brain Injury in Neonatal Rats on Behavioral Parameters and Expression of CDK8 in the Brain Tissue".BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE 174..1(2022):13-17
