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An MRI-Based Radiomics Nomogram to Assess Recurrence Risk in Sinonasal Malignant Tumors

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单位: [1]Qingdao Univ, Dept Radiol, Affiliated Hosp, Qingdao 266003, Shandong, Peoples R China [2]Capital Med Univ, Beijing Friendship Hosp, Dept Radiol, Beijing, Peoples R China [3]Qingdao Univ, Dept Otolaryngol, Affiliated Hosp, Qingdao, Shandong, Peoples R China
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关键词: radiomics sinonasal malignant tumors recurrence

摘要:
Background: Sinonasal malignant tumors (SNMTs) have a high recurrence risk, which is responsible for the poor prognosis of patients. Assessing recurrence risk in SNMT patients is a current problem. Purpose: To establish an MRI-based radiomics nomogram for assessing relapse risk in patients with SNMT. Study Type: Retrospective. Population: A total of 143 patients with 68.5% females (development/validation set, 98/45 patients). Field Strength/Sequence: A 1.5-T and 3-T, fat-suppressed fast spin echo (FSE) T2-weighted imaging (FS-T2WI), FSE T1-weighted imaging (T1WI), and FSE contrast-enhanced T1WI (T1WI + C). Assessment: Three MRI sequences were used to manually delineate the region of interest. Three radiomics signatures (T1WI and FS-T2WI sequences, T1WI + C sequence, and three sequences combined) were built through dimensional reduction of high-dimensional features. The clinical model was built based on clinical and MRI features. The Ki-67-based and tumor-node-metastasis (TNM) model were established for comparison. The radiomics nomogram was built by combining the clinical model and best radiomics signature. The relapse-free survival analysis was used among 143 patients. Statistical Tests: The intraclass/interclass correlation coefficients, univariate/multivariate Cox regression analysis, least absolute shrinkage and selection operator Cox regression algorithm, concordance index (C index), area under the curve (AUC), integrated Brier score (IBS), DeLong test, Kaplan-Meier curve, log-rank test, optimal cutoff values. A P value < 0.05 was considered statistically significant. Results: The T1 + C-based radiomics signature had best prognostic ability than the other two signatures (T1WI and FS-T2WI sequences, and three sequences combined). The radiomics nomogram had better prognostic ability and less error than the clinical model, Ki-67-based model, and TNM model (C index, 0.732; AUC, 0.765; IBS, 0.185 in the validation set). The cutoff values were 0.2 and 0.7 and then the cumulative risk rates were calculated. Data Conclusion: A radiomics nomogram for assessing relapse risk in patients with SNMT may provide better prognostic ability than the clinical model, Ki-67-based model, and TNM model.

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出版当年[2021]版:
大类 | 2 区 医学
小类 | 2 区 核医学
最新[2025]版:
大类 | 2 区 医学
小类 | 3 区 核医学
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出版当年[2020]版:
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版:
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子: 最新[2023版] 最新五年平均[2021-2025] 出版当年[2020版] 出版当年五年平均[2016-2020] 出版前一年[2019版] 出版后一年[2021版]

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第一作者单位: [1]Qingdao Univ, Dept Radiol, Affiliated Hosp, Qingdao 266003, Shandong, Peoples R China
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通讯机构: [1]Qingdao Univ, Dept Radiol, Affiliated Hosp, Qingdao 266003, Shandong, Peoples R China [*1]Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China
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