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An iron-dependent form of non-canonical ferroptosis induced by labile iron

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收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越：重点期刊

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单位： [1]Beijing Clinical Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China [2]Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious Diseases, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China [3]Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

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关键词： ferroptosis labile iron calcium overload mitochondrial calcium uniporter cell death oncosis apoptosis

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Ferroptosis is a recently identified iron-dependent form of nonapoptotic cell death characterized by reactive oxygen species (ROS) generation and lipid peroxidation. Here, we report a novel iron-dependent form of ferroptosis induced by labile iron and investigate the mechanism underlying this process. We find that labile iron-induced ferroptosis is distinct from canonical ferroptosis and is linked to the mitochondrial pathway. Specifically, the mitochondrial calcium uniporter mediates the ferroptosis induced by labile iron. Interestingly, cells undergoing labile iron-induced ferroptosis exhibit cytoplasmic features of oncosis and nuclear features of apoptosis. Furthermore, labile iron-induced ferroptosis involves a unique set of genes. Finally, labile iron-induced ferroptosis was observed in liver subjected to acute iron overload in vivo. Our study reveals a novel form of ferroptosis that may be implicated in diseases caused by acute injury.© 2022. Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature.

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出版当年[2021]版：

大类 | 1 区

生物学

小类 | 1 区生物学

最新[2025]版：

大类 | 1 区

生物学

小类 | 1 区生物学

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出版当年[2020]版：

Q1 BIOLOGY

最新[2023]版：

Q1 BIOLOGY

影响因子： 最新[2023版] 8 最新五年平均[2021-2025] 7.3 出版当年[2020版] 6.038 出版当年五年平均[2016-2020] 4.754 出版前一年[2019版] 4.611 出版后一年[2021版] 10.384

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第一作者单位： [1]Beijing Clinical Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

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