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Efficacy of Clopidogrel-Aspirin Therapy for Stroke Does Not Exist in CYP2C19 Loss-of-Function Allele Noncarriers With Overweight/Obesity

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收录情况： ◇ SCIE

作者：
Mo, Jinglin[1,2,3,4] * ; Chen, Zimo[1,2,3,4] ; Xu, Jie[1,2,3,4] ; Wang, Anxin[1,2,3,4] ; Dai, Liye[1,2,3,4] ; Cheng, Aichun[1,2,3,4] ; Meng, Xia[1,2,3,4] ; Li, Hao[1,2,3,4] ; Wang, Yongjun[1,2,3,4,5,*1] ; Johnston, S. Claiborne[6] ; Wang, Yilong[5] ; Zhao, Xingquan[5] ; Wang, Zhimin[7] ; Xia, Haiqin[8] ; Li, Bin[9] ; Zhang, Guiru[10] ; Ren, Xudong[11] ; Ji, Chunling[12] ; Zhang, Guohua[13] ; Li, Jianhua[14] ; Lu, Bohua[15] ; Wang, Liping[16] ; Feng, Shutao[17] ; Wang, Dali[18] ; Tang, Weiguo[19] ; Li, Juntao[20] ; Zhang, Hongtian[21] ; Li, Guanglai[22] ; Wang, Baojun[23] ; Chen, Yuhua[24] ; Lian, Ying[25] ; Liu, Bin[18] ; Teng, Junfang[26] ; Sui, Rubo[27] ; Li, Lejun[28] ; Yuan, Zhiling[29] ; Zang, Dawei[30] ; Lu, Zuneng[31] ; Sun, Li[32] ; Wang, Dong[33] ; Hou, Liying[34] ; Yuan, Dongcai[35] ; Cao, Yongliang[36] ; Li, Hui[37] ; Tan, Xiuge[38] ; Wang, Huicong[39] ; Du, Haisong[40] ; Liu, Mingyi[41] ; Wang, Suping[42] ; Liu, Qiuwu[43] ; Zhang, Zhong[44] ; Cui, Qifu[45] ; Wang, Runqing[46] ; Zhao, Jialin[47] ; Zhang, Jiewen[48] ; Zhao, Jianping[49] ; Bi, Qi[50] ; Qi, Xiyou[51] ; Liu, Junyan[52] ; Li, Changxin[53] ; Li, Ling[54] ; Pan, Xiaoping[55] ; Zhang, Junling[56] ; Jiao, Derang[57] ; Han, Zhao[58] ; Qian, Dawei[59] ; Xiao, Jin[60] ; Xing, Yan[61] ; Du, Huishan[62] ; Huang, Guang[63] ; Cui, Yongqiang[64] ; Li, Yan[65] ; Feng, Lianyuan[66] ; Gao, Lianbo[67] ; Xiao, Bo[68] ; Cao, Yibin[69] ; Wu, Yiping[70] ; Liu, Jinfeng[71] ; Zhang, Zhiming[72] ; Dong, Zhengxie[73] ; Wang, Limin[74] ; He, Li[75] ; Wang, Xinchen[76] ; Guo, Xueying[77] ; Wang, Ming[78] ; Wang, Xiaosha[79] ; Jiang, Jiandong[80] ; Zhao, Renliang[81] ; Zhou, Shengnian[82] ; Hu, Hao[83] ; He, Maolin[84] ; Yu, Fengchun[85] ; Ouyang, Quping[86] ; Zhang, Jingbo[87] ; Xu, Anding[88] ; Qi, Xiaokun[89] ; Wang, Lei[90] ; Shi, Fuming[91] ; Guo, Fuqiang[92] ; Wang, Jianfeng[42] ; Zhao, Fengli[93] ; Dou, Ronghua[94] ; Wei, Dongning[95] ; Meng, Qingwei[96] ; Xia, Yilu[97] ; Wang, Shimin[98] ; Xue, Zhangcang[99] ; Xu, Yuming[26] ; Ma, Liping[100] ; Wang, Chun[101] ; Wu, Jiang[102] ; Du, Yifeng[103] ; Wang, Yinzhou[104] ; Xiao, Lijun[105] ; Song, Fucong[106] ; Hu, Wenli[107] ; Chen, Zhigang[108] ; Liu, Qingrui[109] ; Zhang, Jiemin[110] ; Chen, Mei[111] ; Yuan, Xiaodong[112] ; Liu, Zhihui[113] ; Li, Guozhong[114] ; Li, Xiaohong[115] ; Tian, Tingchen[116] ;
单位： [1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China [2]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China [3]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China [4]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China [5]Beijing Tiantan Hosp, Beijing, Peoples R China [6]Univ Texas Austin, Med Sch, Austin, TX 78712 USA [7]Taizhou First Peoples Hosp, Taizhou, Peoples R China [8]Taiyuan Iron & Steel Grp Co Ltd, Gen Hosp, Taiyuan, Shanxi, Peoples R China [9]Dagang Oilfield Gengeal Hosp, Dagang, Peoples R China [10]Penglai Peoples Hosp, Yantai, Peoples R China [11]Third Peoples Hosp Datong, Datong, Peoples R China [12]Fourth Cent Hosp Tianjin, Tianjin, Peoples R China [13]Hebei Med Univ, Hosp 2, Wuhan, Hubei, Peoples R China [14]First Hosp Fangshan Dist, Beijing, Peoples R China [15]Beijing Puren Hosp, Beijing, Peoples R China [16]Tianjin Ninghe Dist Hosp, Tianjin, Peoples R China [17]Peoples Hosp Zhengzhou, Zhengzhou, Henan, Peoples R China [18]North China Coal Med Coll, Affiliated Hosp, Hengshui, Peoples R China [19]Zhejiang Zhoushan Hosp, Zhoushan, Peoples R China [20]Han Dan Cent Hosp, Handan, Peoples R China [21]Zhecheng Peoples Hosp, Shangqiu, Peoples R China [22]Shanxi Med Univ, Hosp 2, Taiyuan, Shanxi, Peoples R China [23]Baotou Cent Hosp, Baotou, Peoples R China [24]Gen Hosp Changjiang River Shipping, Wuhan, Hubei, Peoples R China [25]Dalian Econ & Technol Dev Zone Hosp, Dalian, Peoples R China [26]Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China [27]Liaoning Med, Affiliated Hosp, Dalian, Peoples R China [28]Lianyungang Municipal Hosp TCM, Nanjing, Jiangsu, Peoples R China [29]Cent Hosp Qiu Cty, Bade, Peoples R China [30]Tianjin First Ctr Hosp, Tianjin, Peoples R China [31]Wuhan Univ, Renmin Hosp, Wuhan, Hubei, Peoples R China [32]Qingdao Cent Hosp, Qingdao, Shandong, Peoples R China [33]Baogang Hosp, Baotou, Peoples R China [34]Changzhi City Peoples Hosp Shanxi Prov, Taiyuan, Shanxi, Peoples R China [35]HaLixun Int Peace Hosp, Taocheng, Peoples R China [36]Peoples Hosp Linzi Dist, Zibo, Peoples R China [37]Yantai City Yantai Mt Hosp, Yantai, Peoples R China [38]Beijing Pinggu Dist Hosp, Beijing, Peoples R China [39]Taiyuan Cent Hosp, Taiyuan, Shanxi, Peoples R China [40]Chengde Cent Hosp, Chengde, Peoples R China [41]Shijiazhuang Cent Hosp, Shijiazhuang, Hebei, Peoples R China [42]Dalian Municipal Cent Hosp, Dalian, Peoples R China [43]Xian 141 Hosp, Xian, Shaanxi, Peoples R China [44]Chengdu Third Municipal Peoples Hosp, Chengdu, Sichuan, Peoples R China [45]Chifeng Univ, Affiliated Hosp, Chifeng, Peoples R China [46]Zhengzhou Cent Hosp, Zhengzhou, Henan, Peoples R China [47]Zhejiang Prov Lihuili Hosp, Med Ctr, Ningbo, Zhejiang, Peoples R China [48]Henan Prov Peoples Hosp, Zhengzhou, Henan, Peoples R China [49]Jinzhong City Second Hosp, Jinzhong, Peoples R China [50]Capital Med Univ, Beijing Anzhen Hosp, Beijing, Peoples R China [51]Beijing Huairou Dist Chinese Med Hosp, Beijing, Peoples R China [52]Hebei Med Univ, Hosp 3, Shijiazhuang, Hebei, Peoples R China [53]Shanxi Med Univ, Affiliated Hosp 1, Taiyuan, Shanxi, Peoples R China [54]Hebei Prov Peoples Hosp, Wuhan, Hubei, Peoples R China [55]Guangzhou First Municipal Peoples Hosp, Guangzhou, Guangdong, Peoples R China [56]Cent Hosp Cangzhou, Cangzhou, Peoples R China [57]Chinese Peoples Armed Police Force Med Sch, Affiliated Hosp, Tianjin, Peoples R China [58]Zhejiang Wenzhou Med Coll, Affiliated Hosp 1, Wenzhou, Peoples R China [59]Jilin Cent Hosp, Changchun, Jilin, Peoples R China [60]Anhui Maanshan Cent Hosp, Maanshan, Peoples R China [61]Beijing Aviat Ind Cent Hosp, Beijing, Peoples R China [62]Luhe Hosp, Beijing, Peoples R China [63]Capital Med Univ, Beijing Fuxing Hosp, Beijing, Peoples R China [64]306th Hosp PLA, Beijing, Peoples R China [65]Tianjin Univ Chinese Med, Affiliated Hosp 1, Tianjin, Peoples R China [66]Baiqiuen Int Peace Hosp Peoples Liberat Army, Yantai, Peoples R China [67]China Med Univ, Affiliated Hosp 4, Beijing, Peoples R China [68]Cent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China [69]Tangshan Workers Hosp, Tangshan, Peoples R China [70]1st Hosp Handan, Handan, Peoples R China [71]Yangquan Coal Grp Co Ltd, Gen Hosp, Yangquan, Peoples R China [72]Tianjin Tianhe Hosp, Tianjin, Peoples R China [73]Nantong First Peoples Hosp, Nantong, Peoples R China [74]First Hosp Zhangjiakou City, Zhangjiakou, Peoples R China [75]Sichuan Univ, West China Hosp, Chengdu, Sichuan, Peoples R China [76]Shandong Univ TCM, Affiliated Hosp 2, Jinan, Shandong, Peoples R China [77]Fenyang Hosp Shanxi Prov, Lvliang, Peoples R China [78]Zhejiang Zhoushan Putuo Dist Peoples Hosp, Zhoushan, Peoples R China [79]China Acad Chinese Tradit Med, Xiyuan Hosp, Hefei, Anhui, Peoples R China [80]2 Peoples Hosp East Lianyungang City, Lianyungang, Peoples R China [81]Qingdao Univ, Affiliated Hosp, Med Coll, Qingdao, Shandong, Peoples R China [82]Shandong Univ, Qilu Hosp, Jinan, Shandong, Peoples R China [83]Zibo Hosp Tradit Chinese Med, Jinan, Shandong, Peoples R China [84]Beijing Shijitan Hosp, Beijing, Peoples R China [85]Beijing Haidian Hosp, Beijing, Peoples R China [86]Beijing Shunyi Dist Hosp, Beijing, Peoples R China [87]Dalian Third Municipal Hosp, Dalian, Peoples R China [88]Jinan Univ, Affiliated Hosp 1, Jinan, Shandong, Peoples R China [89]Navy Gen Hosp PLA, Beijing, Peoples R China [90]Beijing Second Artillery Gen Hosp, Beijing, Peoples R China [91]Beijing Daxing Dist Hosp, Beijing, Peoples R China [92]Sichuan Prov Peoples Hosp, Chengdu, Sichuan, Peoples R China [93]Second Hosp Baoding, Baoding, Peoples R China [94]Hosp Combine Tradit Chinese & Western Med Cang Zh, Cangzhou, Peoples R China [95]309th Hosp PLA, Beijing, Peoples R China [96]Liangxiang Hosp Fangshan Dist, Beijing, Peoples R China [97]Tsinghua Univ, HuaXin Hosp, Hosp 1, Beijing, Peoples R China [98]Tianjin Huanhu Hosp, Tianjin, Peoples R China [99]Shijiazhuang First Hosp, Shijiazhuang, Peoples R China [100]Xinzhou City Peoples Hosp, Xinzhou, Peoples R China [101]Sichuan Prov Peoples Hosp Deyang City, Deyang, Peoples R China [102]Jilin Univ, Hosp 1, Changchun, Jilin, Peoples R China [103]Shandong Prov Hosp, Jinan, Shandong, Peoples R China [104]Fujian Prov Hosp, Fuzhou, Fujian, Peoples R China [105]Liaoyang City Third Peoples Hosp, Liaoyang, Peoples R China [106]Handan City Ctr Hosp, Handan, Peoples R China [107]Capital Med Univ, Beijing Chaoyang Hosp, Beijing, Peoples R China [108]Beijing Univ Chinese Med, East Hosp, Beijing, Peoples R China [109]Hebei Med Univ, Hosp 4, Shijiazhuang, Hebei, Peoples R China [110]Soochow Univ, Affiliated Hosp 4, Suzhou, Peoples R China [111]Zhejiang Univ Chinese Med, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China [112]Kailuan Co Ltd, Affiliated Hosp, Tangshan, Peoples R China [113]Weifang Med Univ, Affiliated Hosp, Weifang, Peoples R China [114]Harbin Med Univ, Hosp 1, Harbin, Heilongjiang, Peoples R China [115]Dalian Friendship Hosp, Dalian, Peoples R China [116]Tianjin Dagang Hosp, Tianjin, Peoples R China
出处：
DOI： 10.1161/STROKEAHA.119.026845
ISSN：

关键词： allele aspirin body mass index clopidogrel overweight

摘要：
Background and Purpose- The role of dual-antiplatelet therapy with clopidogrel plus aspirin has been demonstrated to substantially decrease the risk of recurrent stroke among patients with minor stroke and transient ischemic attack. We aimed to determine whether the efficacy of clopidogrel-aspirin therapy among patients with minor stroke / transient ischemic attack was influenced by the stratification of CYP2C19 genotype and body mass index (BMI). Methods- CYP2C19 loss-of-function allele (LoFA) carriers were defined as patients with either LoFA of *2 or *3. Low/normal weight and overweight/obesity was defined as BMI <25 and >= 25 kg/m(2), respectively. Primary outcome was defined as stroke recurrence at 3 months. Results- In a total of 2933 patients, there were 1726 (58.8%) LoFA carriers and 1275 (43.5%) patients with overweight/obesity (BMI >= 25 kg/m(2)). Stratified analyses by LoFA carrying status and BMI, hazard ratios (hazard ratios 95% CIs) of the clopidogrel-aspirin therapy for stroke recurrence were 0.90 (0.60-1.36), 0.87 (0.56-1.35), 0.65 (0.39-1.09), and 0.40 (0.22-0.71) among subgroups of LoFA carriers with overweight/obesity, LoFA carriers with low/normal weight, LoFA noncarriers with overweight/obesity, and LoFA noncarriers with low/normal weight, respectively, with P=0.049 for interaction. Conclusions- Efficacy of clopidogrel-aspirin therapy in reducing the risk of stroke recurrence is not present in CYP2C19 LoFA noncarriers with overweight/obesity. Our study suggests that BMI significantly influences the correlation between CYP2C19 genotype and efficacy of clopidogrel-aspirin therapy.

基金：
Ministry of Science and Technology of The People's Republic of ChinaMinistry of Science and Technology, China [2016YFC0901001/2016YFC0 901002/2017YFC1310901]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81701141]; Young Scientist Program [YSP201704]; Young Elite Scientists Sponsorship Program by China Association for Science and Technology [2018QNRC001]
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 2 区 医学
小类 | 2 区 临床神经病学 2 区 外周血管病
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 临床神经病学 1 区 外周血管病
JCR分区：
出版当年[2018]版：
Q1 CLINICAL NEUROLOGY Q1 PERIPHERAL VASCULAR DISEASE
最新[2023]版：
Q1 CLINICAL NEUROLOGY Q1 PERIPHERAL VASCULAR DISEASE

影响因子： 最新[2023版] 最新五年平均[2021-2025] 出版当年[2018版] 出版当年五年平均[2014-2018] 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者单位： [1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China [2]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China [3]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China [4]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China
通讯作者：
通讯机构： [1]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China [2]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China [3]Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China [4]Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China [5]Beijing Tiantan Hosp, Beijing, Peoples R China [*1]119 S 4th Ring W Rd, Beijing 100070, Peoples R China
推荐引用方式(GB/T 7714)：
Mo Jinglin,Chen Zimo,Xu Jie,et al.Efficacy of Clopidogrel-Aspirin Therapy for Stroke Does Not Exist in CYP2C19 Loss-of-Function Allele Noncarriers With Overweight/Obesity[J].STROKE.2020,51(1):224-231.doi:10.1161/STROKEAHA.119.026845.
APA：
Mo, Jinglin,Chen, Zimo,Xu, Jie,Wang, Anxin,Dai, Liye...&Tian, Tingchen.(2020).Efficacy of Clopidogrel-Aspirin Therapy for Stroke Does Not Exist in CYP2C19 Loss-of-Function Allele Noncarriers With Overweight/Obesity.STROKE,51,(1)
MLA：
Mo, Jinglin,et al."Efficacy of Clopidogrel-Aspirin Therapy for Stroke Does Not Exist in CYP2C19 Loss-of-Function Allele Noncarriers With Overweight/Obesity".STROKE 51..1(2020):224-231

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