单位：[1]Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Virology Laboratory, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Beijing 100045, China首都医科大学附属北京儿童医院[2]Department of Microbiology, School of Basic Medical Sciences, Chinese Capital Medical University, Beijing 100069, China[3]Beijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Second Clinical Medical College of Capital Medical University, Beijing 100050, China首都医科大学附属北京友谊医院[4]Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing 100069, China
The development of an effective tetravalent vaccine against dengue viruses (DENVs) has become a world priority. We previously showed that four monovalent dengue DNA vaccines expressing premembrane (prM) and envelope (E) proteins displayed effective protection against corresponding challenges in mice. Thus, to elucidate the overall immunity and persistence of the tetravalent formulation (TetraME), we evaluated the humoral and cellular immune responses as well as the long-term protection in the current study. TetraME-immunized mice displayed increased production of Th1/Th2-typed cytokines upon stimulation with heterologous DENV antigens. Moreover, high levels of tetravalent DENV antibodies and sterilized immunity were detected long-term (30 weeks after immunization). These findings provide feasible validation for the potential utility of this vaccine formulation.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81772172, 81671971, U1602223]
第一作者单位：[1]Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Virology Laboratory, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Beijing 100045, China[2]Department of Microbiology, School of Basic Medical Sciences, Chinese Capital Medical University, Beijing 100069, China
共同第一作者：
通讯作者：
通讯机构：[2]Department of Microbiology, School of Basic Medical Sciences, Chinese Capital Medical University, Beijing 100069, China[4]Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing 100069, China
推荐引用方式(GB/T 7714)：
Ran Wang,Fu-Jia Yang,Xiao-Yan Zheng,et al.Long-term protection against dengue viruses in mice conferred by a tetravalent DNA vaccine candidate[J].ZOOLOGICAL RESEARCH.2020,41(1):90-93.doi:10.24272/j.issn.2095-8137.2020.016.
APA：
Ran Wang,Fu-Jia Yang,Xiao-Yan Zheng,Xian-Zheng Liao,Dong-Ying Fan...&Jing An.(2020).Long-term protection against dengue viruses in mice conferred by a tetravalent DNA vaccine candidate.ZOOLOGICAL RESEARCH,41,(1)
MLA：
Ran Wang,et al."Long-term protection against dengue viruses in mice conferred by a tetravalent DNA vaccine candidate".ZOOLOGICAL RESEARCH 41..1(2020):90-93
生物学