单位：[1]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China[2]Department of Respiration, Qingdao Municipal Hospital, Qingdao, Shandong, China[3]Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China[4]Department of Respiration, The Second Hospital of Hebei Medical University, Shijiazhuang, China[5]Department of Respiration, Qinghai People's Hospital, Xining, China[6]Department of Respiratory Diseases, General Hospital of Shenyang Military Command, Shenyang, China[7]Department of Respiration, The First Affiliated Hospital of Lanzhou University, Lanzhou, China[8]Department of Pulmonary and Critical Care Medicine, The Second Hospital of Jilin University, Changchun,China[9]Department of Respiration, Tongji Hospital, Wuhan, China华中科技大学同济医学院附属同济医院[10]Department of Respiration, Xinqiao Hospital, Third Military Medical University, Chongqing, China[11]Department of Respiration, General Hospital of Ningxia Medical University, Yinchuan, China[12]Department of Pulmonary and Critical Care Medicine, Inner Mongolia People's Hospital, Hohhot, China[13]Department of Respiration, The First Affiliated Hospital of Guangxi Medical University, Nanning, China[14]Department of Respiration, Henan Provincial People's Hospital, Zhengzhou, China[15]Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China江苏省人民医院[16]Department of Respiration, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China[17]Department of Respiration, Xiangya Hospital, Changsha, China[18]Department of Pulmonary and Critical Care Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China[19]Department of Respiration, The First Affiliated Hospital of Harbin Medical University, Harbin China[20]Department of Respiration, Guizhou Provincial People's Hospital, Guiyang, China[21]Department of Respiration, Shanghai Central Hospital, Shanghai, China[22]Department of Respiration, Tianjin First Central Hospital, Tianjin, China[23]Department of Respiration, The First Affiliated Hospital of Nanchang University, Nanchang, China[24]Department of Respiration, Hainan General Hospital, Haikou, China[25]Department of Respiration, Kunming General Hospital of the People's Liberation Army, Kunming, China[26]Department of Respiration, The First Affiliated Hospital of Anhui Medical University, Hefei, China[27]Department of Respiration, Nanfang Hospital, Guangzhou, China[28]Department of Respiration, Shanxi Bethune Hospital, Taiyuan, China[29]Department of Respiration, The First Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou, China浙江大学医学院附属第一医院
Purpose: Details of patients hospitalized for asthma exacerbation in mainland China are lacking. To improve disease control and reduce economic burden, a large sample survey among this patient population is indispensable. This study aimed to investigate the clinical characteristics and outcomes of such patients. Methods: A retrospective study was conducted on patients hospitalized for asthma exacerbation in 29 hospitals of 29 regions in mainland China during the period 2013 to 2014. Demographic features, pre-admission conditions, exacerbation details, and outcomes were summarized. Risk factors for exacerbation severity were analyzed. Results: There were 3,240 asthmatic patients included in this study (57.7% females, 42.3% males). Only 28.0% used daily controller medications; 1,287 (39.7%) patients were not currently on inhaled corticosteroids. Acute upper airway infection was the most common trigger of exacerbation (42.3%). Patients with severe to life-threatening exacerbation tended to have a longer disease course, a smoking history, and had comorbidities such as hypertension, chronic obstructive pulmonary disease (COPD), and food allergy. The multivariate analysis showed that smoking history, comorbidities of hypertension, COPD, and food allergy were independent risk factors for more severe exacerbation. The number of patients hospitalized for asthma exacerbation varied with seasons, peaking in March and September. Eight patients died during the study period (mortality 0.25%). Conclusions: Despite enhanced education on asthma self-management in China during recent years, few patients were using daily controller medications before the onset of their exacerbation, indicating that more educational efforts and considerations are needed. The findings of this study may improve our understanding of hospital admission for asthma exacerbation in mainland China and provide evidence for decision-making.
基金：
Capital Clinical Application Research Foundation of Beijing Municipal Science and Technology Committee [2015-BKJ-001]
第一作者单位：[1]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China
通讯作者：
通讯机构：[1]Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China[*1]Department of Pulmonary and Critical Care
推荐引用方式(GB/T 7714)：
China Asthma Research Network,Lin Jiangtao,Xing Bin,et al.Hospitalization Due to Asthma Exacerbation: A China Asthma Research Network (CARN) Retrospective Study in 29 Provinces Across Mainland China[J].ALLERGY ASTHMA & IMMUNOLOGY RESEARCH.2020,12(3):485-495.doi:10.4168/aair.2020.12.3.485.
APA：
China Asthma Research Network,Lin, Jiangtao,Xing, Bin,Tang, Huaping,Yang, Lan...&Zhou, Jianying.(2020).Hospitalization Due to Asthma Exacerbation: A China Asthma Research Network (CARN) Retrospective Study in 29 Provinces Across Mainland China.ALLERGY ASTHMA & IMMUNOLOGY RESEARCH,12,(3)
MLA：
China Asthma Research Network,et al."Hospitalization Due to Asthma Exacerbation: A China Asthma Research Network (CARN) Retrospective Study in 29 Provinces Across Mainland China".ALLERGY ASTHMA & IMMUNOLOGY RESEARCH 12..3(2020):485-495
