单位：[1]Department of Respiratory and Infectious Disease of Geriatrics, The First Hospital of China Medical University, Shenyang 110001, China[2]Department of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, China[3]Department of Pathology, Shengjing Hospital of China Medical University, Shenyang 110001, China中国医科大学附属盛京医院[4]The First Laboratory of Cancer Institute, The First Hospital of China Medical University, Shenyang 110001, China[5]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China[6]Graduate School of Peking Union Medical College, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China[7]Department of Medical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, Zhejiang, China
G-protein-signaling modulator 2 (GPSM2) belongs to a protein family that regulates activation of G proteins and plays an important role in mitotic spindle orientation. However, the role of GPSM2 in lung adenocarcinoma (LUAD) is still unclear. In this study, it was found that GPSM2 correlates with clinicopathological features and patient's prognosis in LUAD. Knocking down GPSM2 promoted LUAD cell proliferation in vitro and in vivo. Mechanistically, it was demonstrated that GPSM2 knockdown accelerates cell proliferation via the EGFR pathway. These results confirmed that GPSM2 played an important role in LUAD. Moreover, GPSM2, as an independent prognostic factor, may serve as a potential drug target and prognostic biomarker in LUAD.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81972197, 81472193]
第一作者单位：[1]Department of Respiratory and Infectious Disease of Geriatrics, The First Hospital of China Medical University, Shenyang 110001, China[5]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China[6]Graduate School of Peking Union Medical College, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Respiratory and Infectious Disease of Geriatrics, The First Hospital of China Medical University, Shenyang 110001, China[4]The First Laboratory of Cancer Institute, The First Hospital of China Medical University, Shenyang 110001, China[*1]Department of Respiratory and Infectious Disease of Geriatrics, The First Hospital of China Medical University, NO.155, North Nanjing Street, Heping District, Shenyang 110001, China[*2]The First Laboratory of Cancer Institute, The First Hospital of China Medical University, No. 155 North Nanjing Street, Heping District, Shenyang, 110001, China.
推荐引用方式(GB/T 7714)：
Deng M,Liu B,Zhang Z,et al.Loss of G-protein-signaling modulator 2 accelerates proliferation of lung adenocarcinoma via EGFR signaling pathway[J].INTERNATIONAL JOURNAL of BIOCHEMISTRY & CELL BIOLOGY.2020,122:doi:10.1016/j.biocel.2020.105716.
APA：
Deng, M,Liu, B,Zhang, Z,Chen, Y,Wang, Y...&Hu, X.(2020).Loss of G-protein-signaling modulator 2 accelerates proliferation of lung adenocarcinoma via EGFR signaling pathway.INTERNATIONAL JOURNAL of BIOCHEMISTRY & CELL BIOLOGY,122,
MLA：
Deng, M,et al."Loss of G-protein-signaling modulator 2 accelerates proliferation of lung adenocarcinoma via EGFR signaling pathway".INTERNATIONAL JOURNAL of BIOCHEMISTRY & CELL BIOLOGY 122.(2020)
