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YAP promotes gastric cancer cell survival and migration/invasion via the ERK/endoplasmic reticulum stress pathway

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收录情况： ◇ SCIE

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单位： [1]Department of Gastrointestinal Surgery, China‑Japan Friendship Hospital, Beijing 100029 [2]Department of Pharmacy, Beijing Children's Hospital, Capital Medical University, Beijing 100045 [3]Department of Pharmaceutical Engineering, College of Pharmacy, Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, P.R. China

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关键词： yes-associated protein gastric cancer ERK endoplasmic reticulum stress

摘要：

Yes-associated protein (YAP) has been reported to serve an important role in gastric cancer cell survival and migration. However, the underlying mechanism remains unclear. The aim of present study was to identify the underlying mechanism through which Yap sustains gastric cancer viability and migration. The results of the present study demonstrated that YAP expression was upregulated in gastric cancer MKN-28/74 cells compared with normal gastric GES-1 cells. Functional studies revealed that silencing of YAP inhibited gastric cancer MKN-28/74 cell viability and invasion. Mechanistically, YAP may promote gastric cancer cell survival and migration/invasion by inhibiting the endoplasmic reticulum (ER) stress pathway. In addition, YAP may regulate ER stress by activating the ERK signaling pathway. The results of the present study suggested that YAP may be a tumor promoter in gastric cancer and act through the ERK/ER stress pathway; therefore, YAP may have potential implications for new approaches to gastric cancer therapy.

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出版当年[2018]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

JCR分区：

出版当年[2017]版：

Q4 ONCOLOGY

最新[2023]版：

Q3 ONCOLOGY

影响因子： 最新[2023版] 2.5 最新五年平均[2021-2025] 2.4 出版当年[2017版] 1.664 出版当年五年平均[2013-2017] 1.654 出版前一年[2016版] 1.39 出版后一年[2018版] 1.871

第一作者：

第一作者单位： [1]Department of Gastrointestinal Surgery, China‑Japan Friendship Hospital, Beijing 100029

通讯作者：

通讯机构： [1]Department of Gastrointestinal Surgery, China‑Japan Friendship Hospital, Beijing 100029 [*1]Department of Gastrointestinal Surgery, China‑Japan Friendship Hospital, 2 Yinghua Road, Beijing 100029, P.R. China

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