单位：[1]Peking University People’s Hospital, Beijing, China,[2]General Hospital of Hebi Coal Industry (Group)Co., Ltd., Hebi, China,[3]The Third Affiliated Hospital of Southern Medical University, Guangzhou, China,[4]The Second Xiangya Hospital of Central South University, Changsha, China,[5]CNPC Central Hospital, Hebei, China,[6]Gansu Provincial Hospital, Lanzhou, China,[7]Beijing Pinggu Hospital, Beijing, China,[8]Beijing Huairou Hospital of University of Chinese Academy Sciences, Beijing, China,[9]Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian, China,大连市中心医院[10]The General Hospital of Shenyang Military Region, Shenyang, China,[11]Fuwai Hospital Chinese Academy of Medical Sciences, Beijing, China,[12]The First People’s Hospital of Xiangtan City, Xiangtan, China,[13]Shandong Provincial Hospital, Shandong, China,[14]Peking University First Hospital, Beijing, China,[15]The First Affiliated Hospital of Guangxi Medical University, Guangxi, China,[16]Beijing Hospital, Beijing, China,[17]China-Japan Friendship Hospital, Beijing, China,[18]Shengjing Hospital of China Medical University, Shenyang, China,中国医科大学附属盛京医院[19]First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China,中山大学附属第一医院[20]Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China,中山大学附属第二医院[21]The General Hospital of the People’s Liberation Army (301 Hospital), Beijing, China,[22]The General Hospital of Chinese People’s Armed Police Forces, Beijing, China,[23]General Hospital, Tianjin Medical University, Tianjin, China,[24]Guangdong General Hospital, Guangzhou, China广东省人民医院
Type 2 diabetes [T2D] and thyroid dysfunction [TD] often co-occur, have overlapping pathologies, and their risk increases with age. Since 1995, universal salt iodization has been implemented in China to prevent disorders caused by iodine deficiency. However, after two decades of implementation of universal salt iodization, the prevalence of TD in elderly Chinese patients with T2D is not well described and may have been underestimated. We conducted a questionnaire-based survey across 24 endocrinology centers in China between December 2015 and July 2016. Demographic and clinical data from 1677 patients with T2D were obtained and analyzed to examine the prevalence of TD along with T2D in these patients. We assessed TD prevalence according to the four TD subtypes [subclinical hypothyroidism, clinical hypothyroidism, subclinical hyperthyroidism, and clinical hyperthyroidism], TD history, gender, and age. The diagnosis rates were calculated for TD and also for the TD subtype. The number of patients reaching treatment goals for T2D [hemoglobin A1c < 7%] and TD [normal free thyroxine and thyroid-stimulating hormone [TSH]] and the incidences of complications and comorbidities were recorded. Among the enrolled patients with T2D [N = 1677], TD was diagnosed in 23.79% [399/1677] out of which 61% (245/399) were previously diagnosed and 38.59% (154/399) were newly diagnosed cases. Subclinical hypothyroidism, clinical hypothyroidism, subclinical hyperthyroidism, and clinical hyperthyroidism were reported in 4.89%, 9.3%, 1.13%, and 3.16% of the total population, respectively. Among patients previously diagnosed with TD, the incidence in women [166/795; 20.88%] was higher than in men [79/882; 8.96%]. The treatment goals for TD and T2D were attained in 39.6% [97/245] and 34.41% [577/1677] of the cases, respectively. Diabetic complications and comorbidities were reported in 99.7% of patients, with peripheral neuropathy being the most common [43.46%] followed by cataract [24.73%]. We had found that the incidences of dyslipidemia, elevated LDL levels, and osteoporosis were significantly higher in patients with TD than those without TD. TD is underdiagnosed in elderly Chinese patients with T2D.
基金：
Merck Serono China Co. Ltd., an affiliate of Merck KGaA, Darmstadt, Germany
第一作者单位：[1]Peking University People’s Hospital, Beijing, China,
通讯作者：
推荐引用方式(GB/T 7714)：
Yu Zhu,Fengmei Xu,Jie Shen,et al.Prevalence of thyroid dysfunction in older Chinese patients with type 2 diabetes-A multicenter cross-sectional observational study across China[J].PLOS ONE.2019,14(5):doi:10.1371/journal.pone.0216151.
APA：
Yu Zhu,Fengmei Xu,Jie Shen,Youshuo Liu,Changhua Bi...&Linong Ji.(2019).Prevalence of thyroid dysfunction in older Chinese patients with type 2 diabetes-A multicenter cross-sectional observational study across China.PLOS ONE,14,(5)
MLA：
Yu Zhu,et al."Prevalence of thyroid dysfunction in older Chinese patients with type 2 diabetes-A multicenter cross-sectional observational study across China".PLOS ONE 14..5(2019)
