单位：[1]Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China[2]School of Public Health, Peking University, Beijing, China[3]Department of Infectious Diseases, Shengjing Hospital, China Medical University, Shenyang, China中国医科大学附属盛京医院[4]kArtificial Liver Center,Beijing Youan Hospital, Capital Medical University, Beijing, China[5]Department of Gynecology and Obstetrics, Beijing Youan Hospital, Capital Medical University, Beijing, China[6]Department of Gynecology and Obstetrics, The Second Affiliated Hospital of the Southeast University, Nanjing, China[7]Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China临床科室国家中心肝病分中心首都医科大学附属北京友谊医院[8]Department of Infectious Diseases, Southwest Hospital, Army Medical University, Chongqing, China[9]School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China[10]China Foundation for Hepatitis Prevention and Control, Beijing, China[11]Peking University Hepatology Institute, Peking University People’s Hospital, Beijing, China[12]Department of Infectious Diseases, Ruijin Hospital, Shanghai, China
In areas where hepatitis B virus (HBV) is endemic, motherto-child transmission (MTCT) is the major route of infection of children. Blocking MTCT of HBV therefore would reduce its prevalence. The China Foundation of Hepatitis Prevention and Control organized a team of specialists in infectious diseases, hepatology, immunology, obstetrics, and public health to develop an algorithm for interrupting MTCT of HBV, based on the most recent hepatitis B guidelines and latest evidence. This algorithm comprises 10 steps and has been adopted in clinical practice in China. Four aspects (screening, antiviral intervention during pregnancy, immunoprophylaxis, and postvaccination serologic testing) are the core components of preventing MTCT. Although the combination of passive and active immunization in newborns of hepatitis B surface antigen-positive mothers reduces MTCT of HBV, this immunoprophylaxis cannot completely eradicate MTCT. In the past decade, administration of antiviral agents to pregnant women has been shown to be safe and effective in reducing MTCT of HBV in combination with immunoprophylaxis. Aiming to achieve zero MTCT, this algorithm recommends the use of antivirals during pregnancy by women with high viral loads. Preventing MTCT is key to achieving the goal of eliminating HBV as a public health threat by 2030. Implementation and enhancement of the standardized algorithm for pregnant women with chronic HBV infection and their infants is urgently needed to prevent MTCT.
基金：
Chinese National Research Grant of the Thirteenth Five-Year Plan for Key Projects in Infectious Diseases [2017ZX10201201]; Guangzhou Science and Technology Project [201604020010]
第一作者单位：[1]Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China[*1]Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515 China.
通讯作者：
通讯机构：[1]Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China[*1]Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515 China.
推荐引用方式(GB/T 7714)：
Jinlin Hou,Fuqiang Cui,Yang Ding,et al.Management Algorithm for Interrupting Mother-to-Child Transmission of Hepatitis B Virus[J].CLINICAL GASTROENTEROLOGY and HEPATOLOGY.2019,17(10):1929-+.doi:10.1016/j.cgh.2018.10.007.
APA：
Jinlin Hou,Fuqiang Cui,Yang Ding,Xiaoguang Dou,Zhongping Duan...&Hui Zhuang.(2019).Management Algorithm for Interrupting Mother-to-Child Transmission of Hepatitis B Virus.CLINICAL GASTROENTEROLOGY and HEPATOLOGY,17,(10)
MLA：
Jinlin Hou,et al."Management Algorithm for Interrupting Mother-to-Child Transmission of Hepatitis B Virus".CLINICAL GASTROENTEROLOGY and HEPATOLOGY 17..10(2019):1929-+
医学