Carotid Artery Plaques, Carotid Intima-Media Thickness, and Risk of Cardiovascular Events and All-Cause Death in Older Adults: A 5-Year Prospective, Community-Based Study
单位：[1]Evidence-based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院[2]Department of vascular ultrasonography, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院[3]Geriatric department, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院[4]Geriatric department, Friendship Hospital, Capital Medical University, Beijing, China首都医科大学附属北京友谊医院
We assessed the effect of asymptomatic carotid atherosclerosis (CAS) on the development of cardiovascular diseases (CVDs) in a community-based population aged 55 years in China. A total of 1376 residents underwent CAS assessment by ultrasonography in July 2009. New CVD events, including stroke and coronary heart events, were collected at the follow-up survey at the end of 2014. After adjusting for baseline demographic characteristics and traditional CVD risk factors, the risk of CVD in patients with minimal CAS (mean common carotid artery intima-media thickness [CCA-IMT] 1 mm and no plaques), nonstenotic plaques (carotid stenosis <50%), and stenotic plaques (carotid stenosis 50%) was 0.8 (hazard ratio [HR]: 0.75, 95% confidence interval [CI]: 0.33-1.69), 2.0 (HR: 2.01, 95% CI: 1.24-3.25), and 3.1 (HR: 3.05, 95% CI: 1.62-5.74) times greater, respectively, than that of patients without CAS (CCA-IMT <1 mm and no plaques). Our findings provide direct evidence of the independent predictive value of the severity of asymptomatic CAS for the development of CVD in older Chinese adults.
基金：
Commission of Science and Technology of Beijing [D121100004912002]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7152068]; Xuanwu Hospital, Capital Medical University, Beijing, China
第一作者单位：[1]Evidence-based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Evidence-based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing, China[*1]Evidence-based Medical Center, Xuanwu Hospital, Capital Medical University, #45 Changchun Street, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Zhang Yanlei,Fang Xianghua,Hua Yang,et al.Carotid Artery Plaques, Carotid Intima-Media Thickness, and Risk of Cardiovascular Events and All-Cause Death in Older Adults: A 5-Year Prospective, Community-Based Study[J].ANGIOLOGY.2018,69(2):120-129.doi:10.1177/0003319717716842.
APA：
Zhang, Yanlei,Fang, Xianghua,Hua, Yang,Tang, Zhe,Guan, Shaochen...&Liu, Chunxiao.(2018).Carotid Artery Plaques, Carotid Intima-Media Thickness, and Risk of Cardiovascular Events and All-Cause Death in Older Adults: A 5-Year Prospective, Community-Based Study.ANGIOLOGY,69,(2)
MLA：
Zhang, Yanlei,et al."Carotid Artery Plaques, Carotid Intima-Media Thickness, and Risk of Cardiovascular Events and All-Cause Death in Older Adults: A 5-Year Prospective, Community-Based Study".ANGIOLOGY 69..2(2018):120-129
