Antimicrobial susceptibilities of aerobic and facultative gram-negative bacilli isolated from Chinese patients with urinary tract infections between 2010 and 2014
单位：[1]Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.[2]Department of Respiratory and Critical Care Medicine, Clinical Microbiology and Infectious Disease Lab., China-Japan Friendship Hospital, Beijing 100029, China.[3]Department of Microbiology, The First Affiliated Hospital of Zhejiang University, Hangzhou 310003, China.浙江大学医学院附属第一医院[4]Division of Microbiology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China.[5]Department of Infectious Diseases, SirRunRun Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.[6]Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.华中科技大学同济医学院附属同济医院[7]Division of Microbiology, Zhongshan Hospital of Fudan University, Shanghai 200032, China[8]Division of Microbiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.重庆医科大学附属第一医院[9]Department of Laboratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China[10]Infection control center, Xiangya Hospital, Central South University, Changsha 410008, China.[11]Division of Microbiology, The First Affiliated Hospital of Zhengzhou University, Zhenzhou 450052, China.[12]Division of Microbiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.院本部中山大学附属第一医院[13]Department of Microbiology, The Chinese PLA General Hospital, Beijing 100853, China.[14]Division of Microbiology, Tianjin Medical University General Hospital, Tianjing 300052, China.[15]Division of Microbiology, The First Affiliated Hospital of Chinese Medical University, Shenyang 110001, China.[16]Department of Clinical Laboratory, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.[17]Department of Clinical Laboratory, Beijing Friendship Hospital of Capital Medical University, Beijing 100020, China.医技科室检验科检验科首都医科大学附属北京友谊医院[18]Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.[19]Microbiology Lab, Jilin Province People’s Hospital, Changchun 130021, China.[20]Division of Microbiology, Haikou People’s Hospital, Haikou 570208, China.[21]Division of Microbiology, General Hospital of Nanjing Military Command, Nanjing 210002, China.[22]Division of Microbiology, International Health Management Associates, Schaumburg, IL 60173-3817, USA.
Background: The objective of this study was to investigate the distribution and susceptibility of aerobic and facultative Gram-negative bacilli isolated from Chinese patients with UTIs collected within 48 h (community acquired, CA) or after 48 h (hospital acquired, HA) of hospital admission. Methods: From 2010 to 2014, the minimum inhibitory concentrations (MICs) of 12 antibiotics for 4,332 aerobic and facultative Gram-negative bacilli, sampled in 21 hospitals in 16 cities, were determined by the broth microdilution method. Results: Enterobacteriaceae composed 88.5% of the total isolates, with Escherichia coli (E. coli) (63.2%) the most commonly isolated species, followed by Klebsiella pneumoniae (K. pneumoniae) (12.2%). Non-Enterobacteriaceae accounted for only 11.5% of all isolates and included mainly Pseudomonas aeruginosa (P. aeruginosa) (6.9%) and Acinetobacter baumannii (A. baumannii) (3.3%). Among the antimicrobial agents tested, the susceptibility rates of E. coli to the two carbapenems, ertapenem and imipenem as well as amikacin and piperacillin-tazobactam ranged from 92.5 to 98.7%. Against K. pneumonia, the most potent antibiotics were imipenem (92.6% susceptibility), amikacin (89.2% susceptibility) and ertapenem (87.9% susceptibility). Although non-Enterobacteriaceae did not show high susceptibilities to the 12 common antibiotics, amikacin exhibited the highest in vitro activity against P. aeruginosa over the 5-year study period, followed by piperacillintazobactam, imipenem, ceftazidime, cefepime, ciprofloxacin, and levofloxacin. The Extended Spectrum BetaLactamase (ESBL) rates decreased slowly during the 5 years in E. coli from 68.6% in 2010 to 59.1% in 2014, in K. pneumoniae from 59.7 to 49.2%, and in Proteus mirabilis (P. mirabilis) from 40.0 to 26.1%. However, the ESBL rates were different in 5 regions of China (Northeast, North, East, South and Middle-China). Conclusion: E. coli and K. pneumonia were the major pathogens causing UTIs and carbapenems and amikacin retained the highest susceptibility rates over the 5-year study period, indicating that they are good drug choices for empirical therapies, particularly of CA UTIs in China.
基金：
Merck Sharp Dohme (MSD; Whitehouse Station, NJ, USA); CAMS Initiative for Innovative Medicine [2016-I2M-3-014]
第一作者单位：[1]Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
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推荐引用方式(GB/T 7714)：
Yang Qiwen,Zhang Hui,Wang Yao,et al.Antimicrobial susceptibilities of aerobic and facultative gram-negative bacilli isolated from Chinese patients with urinary tract infections between 2010 and 2014[J].BMC INFECTIOUS DISEASES.2017,17:doi:10.1186/s12879-017-2296-x.
APA：
Yang, Qiwen,Zhang, Hui,Wang, Yao,Xu, Zhipeng,Zhang, Ge...&Badal, Robert E..(2017).Antimicrobial susceptibilities of aerobic and facultative gram-negative bacilli isolated from Chinese patients with urinary tract infections between 2010 and 2014.BMC INFECTIOUS DISEASES,17,
MLA：
Yang, Qiwen,et al."Antimicrobial susceptibilities of aerobic and facultative gram-negative bacilli isolated from Chinese patients with urinary tract infections between 2010 and 2014".BMC INFECTIOUS DISEASES 17.(2017)
