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Percent free prostate-specific antigen is effective to predict prostate biopsy outcome in Chinese men with prostate-specific antigen between 10.1 and 20.0 ng ml(1)

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收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C

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单位： [1]Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, 200433 China [2]Department of Urology, Peking University FirstHospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing 100034, China [3]Department of Health Care, PLA Headquarters of the GeneralStaff Guard Bureau, Beijing 100017, China [4]Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China [5]Department of Urology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200127, China [6]Department of Urology, First Affiliated Hospital ofMedical School, Xi’an Jiaotong University, Xi’an 710061, China [7]Department of Urology, Huashan Hospital, Fudan University, Shanghai 200040, China [8]Department ofUrology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China [9]State Key Laboratory of Reproductive Medicine, Department of Urology, The FirstAffiliated Hospital of Nanjing Medical University, Nanjing 210029, China [10]Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050,China [11]Department of Urology, Huadong Hospital, Fudan University, Shanghai 20040, China [12]Department of Urology, Shanghai Jiao Tong University Affiliated SixthPeople’s Hospital, Shanghai 200233, China [13]Department of Urology, Peking University Third Hospital, Beijing 100083, China [14]Department of Urology, Tenth People’sHospital, Tongji University, Shanghai 200072, China [15]Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430030, China [16]Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai 200032, China [17]Department of Urology, Shanghai ChangzhengHospital, Second Military Medical University, Shanghai 200003, China [18]Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China [19]Department of Urology, Peking University People’s Hospital, Beijing 100044, China [20]Department of Urology, Xijing Hospital, The Fourth Military Medical University,Xi’an 710032, China [21]Department of Urology, Third Hospital of Sun Yat‑Sen University, Guangzhou 510630, China [22]Department of Urology, Zhujiang Hospital, SouthernMedical University, Guangdong 510282, China [23]Department of Urology, Wuhan General Hospital of Guangzhou Military Command, Wuhan 430070, China

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关键词： Chinese population diagnosis percent free prostate-specific antigen prostate cancer prostate carcinoma tumor antigen prostate-specific antigen

摘要：

Percent free prostatic-specific antigen (%fPSA) has been introduced as a tool to avoid unnecessary biopsies in patients with a serum PSA level of 4.0-10.0 ng ml(1) , however, it remains controversial whether %fPSA is effective in PSA range of 10.1-20.0 ng ml(1) in both Chinese and Western population. In this study, the diagnostic performance of %fPSA and serum PSA in predicting prostate cancer (PCa) and high-grade PCa (HGPCa) was analyzed in a multi-center biopsy cohort of 5915 consecutive Chinese patients who underwent prostate biopsy in 22 hospitals across China from January 1, 2010 to December 31, 2013. The indication for biopsy was PSA > 4.0 ng ml(1) or/and suspicious digital rectal examination. Total and free serum PSA determinations were performed by three types of electrochemiluminescence immunoassays with recalibration to the World Health Organization standards. The diagnostics accuracy of PSA, %fPSA and %fPSA in combination with PSA (%fPSA PSA) was determined by the area under the receivers operating characteristic curve (AUC). %fPSA was more effective than PSA in men aged >= 60 years old. The AUC was 0.584 and 0.635 in men aged >= 60 years old with a PSA of 4.0-10.0 ng ml(1) and 10.1-20.0 ng ml(1) , respectively. The AUC of %fPSA was superior to that of PSA in predicting HGPCa in patients >= 60 years old in these two PSA range. Our results indicated that %fPSA is both statistically effective and clinical applicable to predict prostate biopsy outcome in Chinese patients aged >= 60 years old with a PSA of 4.0-10.0 ng ml(1) and 10.1-20.0 ng ml(1) .

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出版当年[2014]版：

大类 | 4 区医学

小类 | 2 区男科学 3 区泌尿学与肾脏学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区男科学 2 区泌尿学与肾脏学

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出版当年[2013]版：

Q2 ANDROLOGY Q2 UROLOGY & NEPHROLOGY

最新[2023]版：

Q1 UROLOGY & NEPHROLOGY Q2 ANDROLOGY

影响因子： 最新[2023版] 3 最新五年平均[2021-2025] 2.7 出版当年[2013版] 2.53 出版当年五年平均[2009-2013] 2.218 出版前一年[2012版] 2.14 出版后一年[2014版] 2.596

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第一作者单位： [1]Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, 200433 China

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Percent free prostate-specific antigen is effective to predict prostate biopsy outcome in Chinese men with prostate-specific antigen between 10.1 and 20.0 ng ml(1)

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