单位：[1]Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Tenth People’s Hospital of Tongji University, Shanghai, China[2]Department of Medical Ultrasonics, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China院本部南沙医院东院超声医学科超声医学科超声医学科超声医学科超声医学科中山大学附属第一医院[3]Department of Ultrasound, Zhongshan Hospital of Fudan University, Shanghai, China[4]Department of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China[5]Department of Ultrasound, Peking University School of Oncology, Beijing Cancer Institute, Beijing, China[6]Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China中国医科大学附属盛京医院[7]Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing, China医技科室影像中心超声医学科首都医科大学附属北京友谊医院[8]Department of Ultrasound, Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China中山大学附属第二医院
The purpose of this study was to evaluate the usefulness of contrast-enhanced ultrasound (CEUS) in the differential diagnosis of gallbladder wall (GBW) thickening and determine the predictors of malignant GBW thickening. One hundred fifty-nine patients with GBW thickening, including 76 men and 83 women, from eight institutions were enrolled. CEUS was performed after injection of a sulfur hexafluoride microbubble-based ultrasound contrast agent. Multiple logistic regression analysis was used to reveal independent predictors associated with malignant GBW thickening. The final diagnoses were 48 gallbladder carcinomas and 111 benign gallbladder diseases. Maximal thicknesses of the GBW in malignant and benign GBW thickening were 17.3 +/- 5.2 (6-30) mm and 8.6 +/- 5.1 (4-26) mm respectively (p < 0.001). CEUS revealed significant differences in intralesional vessels, enhancement homogeneity, time to hypo-enhancement, inner layer discontinuity, outer layer discontinuity and adjacent liver involvement (all p-values < 0.05) between malignant and benign GBW thickening. Patient age > 46.5 y, focal GBW thickening, inner layer discontinuity and outer layer discontinuity were found to be associated with malignancy by multiple logistic regression analysis (all p-values < 0.05). Receiver operating characteristic curve analysis revealed Az values for patient age, focal GBW thickening, inner wall discontinuity and outer wall discontinuity of 0.709 (95% confidence interval [CI]: 0.627-0.790), 0.714 (95% CI: 0.630-0.798), 0.860 (95% CI: 0.791-0.928) and 0.858 (95% CI: 0.783-0.933), respectively. CEUS is useful in the differential diagnosis between malignant and benign GBW thickening. Focal GBW thickening, inner wall discontinuity and outer wall discontinuity observed on CEUS are diagnostic clues for malignant GBW thickening. (C) 2014 World Federation for Ultrasound in Medicine & Biology.
基金：
Shanghai Health and Family Planning Commission [20114003, 2013SY066]; National Natural Scientific Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81301299]; Shanghai Talent Development Project from the Shanghai Human Resource and Social Security Bureau [2012045]
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2013]版：
大类|3 区医学
小类|2 区声学3 区核医学
最新[2025]版：
大类|3 区医学
小类|3 区声学3 区核医学
JCR分区：
出版当年[2012]版：
Q1ACOUSTICSQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q2ACOUSTICSQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者单位：[1]Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Tenth People’s Hospital of Tongji University, Shanghai, China
通讯作者：
通讯机构：[1]Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Tenth People’s Hospital of Tongji University, Shanghai, China[2]Department of Medical Ultrasonics, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China[*1]Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Tenth People’s Hospital of Tongji University, No. 301, Yanchangzhong Road, Shanghai 200072, China
推荐引用方式(GB/T 7714)：
Xu Jun-Mei,Guo Le-Hang,Xu Hui-Xiong,et al.DIFFERENTIAL DIAGNOSIS OF GALLBLADDER WALL THICKENING: THE USEFULNESS OF CONTRAST-ENHANCED ULTRASOUND[J].ULTRASOUND in MEDICINE and BIOLOGY.2014,40(12):2794-2804.doi:10.1016/j.ultrasmedbio.2014.06.015.
APA：
Xu, Jun-Mei,Guo, Le-Hang,Xu, Hui-Xiong,Zheng, Shu-Guang,Liu, Lin-Na...&Luo, Bao-Ming.(2014).DIFFERENTIAL DIAGNOSIS OF GALLBLADDER WALL THICKENING: THE USEFULNESS OF CONTRAST-ENHANCED ULTRASOUND.ULTRASOUND in MEDICINE and BIOLOGY,40,(12)
MLA：
Xu, Jun-Mei,et al."DIFFERENTIAL DIAGNOSIS OF GALLBLADDER WALL THICKENING: THE USEFULNESS OF CONTRAST-ENHANCED ULTRASOUND".ULTRASOUND in MEDICINE and BIOLOGY 40..12(2014):2794-2804
