单位：[1]People’s Hospital, Peking University Health Science Center, Beijing, China[2]People’s Hospital, Peking University Health Science Center, and Peking University Shougang Hospital, Beijing, China[3]Peking University Health Science Center, Beijing, China[4]Peking University Shougang Hospital, Beijing, China[5]Second Affiliated Hospital of Shanxi Medical University, Taiyuan, China[6]First Affiliated Hospital, Baotou Medical College, Baotou, China内蒙古科技大学包头医学院[7]China-Japan Friendship Hospital, Beijing, China[8]Xijing Hospital, Fourth Military Medical University, Xi’an, China[9]Second Affiliated Hospital of Hebei Medical University, Shijiazhuang, China[10]Peking University Third Hospital, Beijing, China[11]Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, China[12]Affiliated Kailuan Hospital of North China Coal Medical University, Tangshan, Hebei, China[13]Peking University First Hospital, Beijing, China[14]Bethune International Peace Hospital of PLA, Shijiazhuang, China[15]Handan Central Hospital, Handan, China[16]People’s Hospital of Hebei Province, Shijiazhuang, China[17]People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China[18]Beijing Shunyi Hospital of China Medical University, Beijing, China[19]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属同济医院[20]First Affiliated Hospital, SUN Yat-sen University, Guangzhou, China中山大学附属第一医院[21]Beijing Hospital, Beijing, China[22]Qilu Hospital of Shandong University, Jinan, China[23]Second Affiliated Hospital of Lanzhou University, Lanzhou, China
ObjectiveTo estimate the annual direct and indirect costs of rheumatoid arthritis (RA) in China and identify the predictors for cost of illness. MethodsA cross-sectional study of cost of illness from the societal perspective was conducted on 829 patients with RA in 21 tertiary care hospitals in China between July 2009 and December 2010. Data on demographics, clinical variables, and components of costs were collected by physician interview. Costs were represented in 2009 US dollars using purchasing power parity estimates. Univariate and multivariate linear regression analyses were performed to identify the predictors for cost of illness. ResultsThe mean SD total cost of RA in China was $3,826 +/- $5,659 per patient-year, given a gross domestic product per capita of $6,798 in China in 2009. Direct costs and indirect costs comprised 90.0% and 10.0% of the total costs, respectively. Drug expense represented approximately half of the total costs, dominated by biologic agents (48.2%) and disease-modifying antirheumatic drugs (23.5%). Additionally, the cost of extracted herbal drugs and traditional Chinese medicine comprised approximate to 17.6% of the drug expense. Higher education level, noninsured status, longer disease duration, more extraarticular manifestations, and higher Health Assessment Questionnaire score independently predicted higher total costs. ConclusionOur results provide the first study of costs of RA in China. This study not only demonstrates the economic burden of RA, but also identifies the predictors that could be interventional factors to reduce the societal costs of RA in China.
基金：
National Basic Research Program of China (973 program)National Basic Research Program of China [2010CB529104]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81072401]
第一作者单位：[1]People’s Hospital, Peking University Health Science Center, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]People’s Hospital, Peking University Health Science Center, Beijing, China[*1]Department of Rheumatology and Immunology,People’s Hospital, Peking University Health Science Center, No. 11 Xizhimen South Street, Western District, Beijing, China
推荐引用方式(GB/T 7714)：
Xu Chuanhui,Wang Xiuru,Mu Rong,et al.Societal Costs of Rheumatoid Arthritis in China: A Hospital-Based Cross-Sectional Study[J].ARTHRITIS CARE & RESEARCH.2014,66(4):523-531.doi:10.1002/acr.22160.
APA：
Xu, Chuanhui,Wang, Xiuru,Mu, Rong,Yang, Li,Zhang, Ye...&Li, Zhanguo.(2014).Societal Costs of Rheumatoid Arthritis in China: A Hospital-Based Cross-Sectional Study.ARTHRITIS CARE & RESEARCH,66,(4)
MLA：
Xu, Chuanhui,et al."Societal Costs of Rheumatoid Arthritis in China: A Hospital-Based Cross-Sectional Study".ARTHRITIS CARE & RESEARCH 66..4(2014):523-531
