单位：[1]Department of Gastroenterology, Changhai Hospital, Second Military Medical University[2]Department of Gastroenterology, Huadong Hospital, Fudan University[3]Department of Gastroenterology, Renji Hospital[4]Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai[5]Department of Gastroenterology, The General Hospital of the People’s Liberation Army (Hospital 301)[6]Department of Gastroenterology, Peking University People’s Hospital[7]Department of Gastroenterology, Beijing Friendship Hospital临床科室国家中心消化分中心消化内科首都医科大学附属北京友谊医院[8]Department of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University北京朝阳医院[9]Department of Gastroenterology, Peking Union Medical College Hospital[10]Department of Gastroenterology, Peking University Third Hospital, Beijing[11]Department of Gastroenterology, Daping Hospital[12]Department of Gastroenterology, Southwest Hospital[13]Department of Gastroenterology, Xinqiao Hospital, The Third Military Medical University, Chongqing[14]Department of Gastroenterology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi’an, Shaanxi[15]Department of Gastroenterology, Guangdong Provincial People’s Hospital[16]Department of Gastroenterology, Guangzhou First Municipal People’s Hospital, Affiliated Guangzhou Medical College[17]Department of Gastroenterology, Nanfang Hospital, Southern Medical University[18]Department of Gastroenterology, The Second Affiliated Hospital of Sun Yat-sen University中山大学附属第二医院[19]Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong院本部南沙医院东院内科消化内科内科消化内科内科消化内科中山大学附属第一医院[20]Department of Gastroenterology, The First People’s Hospital of Hangzhou[21]Department of Gastroenterology, The First affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang浙江大学医学院附属第一医院[22]Department of Gastroenterology, The First Hospital, Jilin University, Changchun, Jinlin[23]Department of Gastroenterology, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi[24]Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing[25]Department of Gastroenterology, The First Affiliated Hospital of Suzhou University, Suzhou, Jiangsu[26]Department of Gastroenterology, Shengjing Hospital of China Medical University中国医科大学附属盛京医院[27]Department of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning[28]Department of Gastroenterology, General Hospital of Tianjin Medical University, Tianjin[29]Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, Hunan, China
Background and Aim Recently, Gastroesophageal Reflux Disease Questionnaire (GerdQ) has been developed for diagnosis of GERD. However, no study investigated its value in real-world practice. This study aimed to investigate whether GerdQ can be used for diagnosis of GERD in China. Methods A national multicenter survey was undertaken; all patients who underwent first diagnostic upper endoscopy for upper gastrointestinal (GI) symptoms were included. Data including the gender, age, symptoms, and endoscopic findings were prospectively recorded. The GerdQ score was measured before endoscopic procedure. Results Totally, 8065 patients were included. One thousand four hundred and thirty-five patients (17.8%) had reflux esophagitis. Among them, 620 (43.2%) patients' GerdQ score was 8. For 2025 patients with GerdQ8, 620 (30.6%) were found to have reflux esophagitis, but the remaining 69.4% (1405/2025) were normal. Proportions of patients with reflux esophagitis increased in cut-off range from 318 for GerdQ. However, 22.2% of the patients with a GerdQ score2 also had reflux esophagitis. Twenty-eight (0.3%) patients were diagnosed to have upper GI malignancies, and 10 out of these 28 (35.7%) patients' GerdQ score was 8. Conclusions The study suggests the proportions of Chinese patients with reflux esophagitis rise up with the increase of GerdQ score, and GerdQ may be used for diagnosis of GERD. However, low GerdQ score cannot exclude the possibility of reflux esophagitis. A minority of Chinese patients has high GerdQ score but is diagnosed with malignancies, even in the absence of alarm features.
基金：
National Key Scientific and Technological Project [2012ZX09303011-002]; AstraZenecaAstraZeneca
第一作者单位：[1]Department of Gastroenterology, Changhai Hospital, Second Military Medical University
通讯作者：
通讯机构：[1]Department of Gastroenterology, Changhai Hospital, Second Military Medical University[*1]Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
推荐引用方式(GB/T 7714)：
Bai Yu,Du Yiqi,Zou Duowu,et al.Gastroesophageal Reflux Disease Questionnaire (GerdQ) in real-world practice: A national multicenter survey on 8065 patients[J].JOURNAL of GASTROENTEROLOGY and HEPATOLOGY.2013,28(4):626-631.doi:10.1111/jgh.12125.
APA：
Bai, Yu,Du, Yiqi,Zou, Duowu,Jin, Zhendong,Zhan, Xianbao...&Zhao, Xiaoyan.(2013).Gastroesophageal Reflux Disease Questionnaire (GerdQ) in real-world practice: A national multicenter survey on 8065 patients.JOURNAL of GASTROENTEROLOGY and HEPATOLOGY,28,(4)
MLA：
Bai, Yu,et al."Gastroesophageal Reflux Disease Questionnaire (GerdQ) in real-world practice: A national multicenter survey on 8065 patients".JOURNAL of GASTROENTEROLOGY and HEPATOLOGY 28..4(2013):626-631
