The association between Human Leukocyte Antigen (HLA) class II and rheumatoid arthritis (RA) has been extensively studied, but few reported DR-DQ haplotype. Here we investigated the association of HLA-DRB1, DQA1, DQB1, and DR-DQ haplotypes with RA susceptibility and with anti-CCP antibodies in 281 RA patients and 297 control in Han population. High-resolution genotyping were performed. The HLA-DRB1 shared epitope (SE)-encoding allele *0405 displayed the most significant RA association (P = 1.35x10(-6)). The grouped DRB1 SE alleles showed great association with RA (P = 3.88x10(-13)). The DRB1 DRRAA alleles displayed significant protective effects (P = 0.021). The SE-dependent DR-DQ haplotype SE-DQ3/4/5 remained strong association with both anti-CCP -positive (P = 3.71x10(-13)) and -negative RA (P = 3.89x10(-5)). Our study revealed that SE alleles and its haplotypes SE-DQ3/4/5 were highly associated with RA susceptibility in Han population. The SE-DQ3/4/5 haplotypes were associated with both anti-CCP positive RA and -negative RA.
基金：
National Basic Research Program of China (973 Program)National Basic Research Program of China [2010CB529105]; General Program of the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30901319]; Program of International Science & Technology Cooperation from MOST [2010DFB34000]; Major International Joint Research Project from Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81120108020]; Doctoral Fund of Ministry of Education of ChinaMinistry of Education, China [20110001110045]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7122196]
第一作者单位：[1]Peking Univ, Dept Rheumatol & Immunol, Peoples Hosp, Beijing 100871, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Xu,Guo Jianping,Jia Yuan,et al.HLA-DRB1 Shared Epitope-Dependent DR-DQ Haplotypes Are Associated with Both Anti-CCP-Positive and -Negative Rheumatoid Arthritis in Chinese Han[J].PLOS ONE.2013,8(8):doi:10.1371/journal.pone.0071373.
APA：
Liu, Xu,Guo, Jianping,Jia, Yuan,Zhao, Yi,Liu, Xia...&Li, ZhangGuo.(2013).HLA-DRB1 Shared Epitope-Dependent DR-DQ Haplotypes Are Associated with Both Anti-CCP-Positive and -Negative Rheumatoid Arthritis in Chinese Han.PLOS ONE,8,(8)
MLA：
Liu, Xu,et al."HLA-DRB1 Shared Epitope-Dependent DR-DQ Haplotypes Are Associated with Both Anti-CCP-Positive and -Negative Rheumatoid Arthritis in Chinese Han".PLOS ONE 8..8(2013)
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