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Symptom combinations assessed in traditional Chinese medicine and its predictive role in ACR20 efficacy response in rheumatoid arthritis

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单位: [1]Guangdong Traditional Chinese Medicine Hospital, Guangzhou, China [2]Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Beijing and E-institute of Shanghai Municipal Education Commission Shanghai TCM University, Shanghai, China [3]Jiangxi TCM University, Nanchang, China [4]Sino-Japan Friendship Hospital, Beijing, China [5]Hubei Traditional Chinese Medicine Academy, Wuhan, China [6]The Affiliated Hospital, Chengdu TCM University, Chengdu, China [7]The Affiliated Hospital, Tianjin Traditional Chinese Medicine College, Tianjin, China [8]Nantong Liangchun TCM Clinical Research Institute, Nantong, China [9]The Longhua Affiliated Hospital, Shanghai Traditional Chinese Medicine University Shanghai, China [10]Guanganmen Hospital, China Academy of Traditional Chinese Medicine, Beijing, China [11]The Jiangsu Traditional Chinese Medicine Hospital, Nanjing, China [12]The Arthritis Research Center, University of British Columbia, Vancouver, Canada
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关键词: symptoms efficacy rheumatoid arthritis

摘要:
The predictive roles of symptom combination traditionally evaluated in traditional Chinese medicine (TCM) in the treatment of rheumatoid arthritis (RA) were explored. Three hundred and ninety six patients were randomly divided into 197 subjects receiving Western medicine therapy (WM) and 199 subjects receiving TCM therapy (TCM). A complete physical examination and 18 clinical manifestations typically assessed in TCM were recorded before the randomization. The ACR responses were used for efficacy evaluation. ACR20 and 50 responses with WM treatment were higher than in the TCM group. The 18 symptoms in RA could be clustered into 4 symptom combinations with factor analysis, which represent joint symptoms, cold pattern, deficiency pattern and hot pattern in TCM respectively. TCM would be more effective in patients with weak-symptom combination 3 (deficiency pattern in TCM), and WM would be more effective in patients with symptom combination 2 (cold pattern in TCM). Symptom combinations judged with TCM may have influence on the efficacy of therapy in the treatment of RA.

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出版当年[2007]版:
大类 | 4 区 医学
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 全科医学与补充医学 2 区 医学:内科
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出版当年[2006]版:
Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Q3 MEDICINE, GENERAL & INTERNAL
最新[2023]版:
Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Q1 MEDICINE, GENERAL & INTERNAL

影响因子: 最新[2023版] 最新五年平均[2021-2025] 出版当年[2006版] 出版当年五年平均[2002-2006] 出版前一年[2005版] 出版后一年[2007版]

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第一作者单位: [1]Guangdong Traditional Chinese Medicine Hospital, Guangzhou, China
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通讯机构: [2]Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Beijing and E-institute of Shanghai Municipal Education Commission Shanghai TCM University, Shanghai, China [*1]Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing 100700, China.
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