详情页 - 聚合机构库演示平台

当前位置：首页 > 详情页

Identification of autoimmune type 1 diabetes and multiple organ-specific autoantibodies in adult-onset non-insulin-requiring diabetes in China: A population-based multicentre nationwide survey

文献详情

资源类型：

WOS体系：

收录情况： ◇ SCIE

作者：

单位： [1]Department of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, China [2]Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, National Clinical Research Centre for Metabolic Diseases, Changsha, China [3]School of Public Health, Central South University, Changsha, China [4]Department of Endocrinology and Metabolism, Chinese People's Liberation Army General Hospital, Beijing, China [5]Department of Endocrinology and Metabolism, First Affiliated Hospital of China Medical University, Shenyang, China [6]Department of Endocrinology and Metabolism, Shanxi Provincial People's Hospital, Taiyuan, China [7]Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China [8]Department of Endocrinology, Xijing Hospital, Fourth Military Medical University, Xi'an, China [9]Department of Endocrinology and Metabolism, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China [10]Department of Endocrinology and Metabolism, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China [11]Departments of Endocrinology and Metabolism, Fujian Provincial Hospital, Fuzhou, China [12]Department of Endocrinology and Metabolism, Qilu Hospital of Shandong University, Jinan, China [13]Department of Endocrinology and Metabolism, Peking University First Hospital, Beijing, China [14]Department of Endocrinology and Metabolism, Henan Provincial People's Hospital, Zhengzhou, China [15]Department of Endocrinology and Metabolism, Second Affiliated Hospital of Harbin Medical University, Harbin, China [16]Department of Endocrinology and Metabolism, Third Affiliated Hospital of Sun Yatsen University, Guangzhou, China [17]Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Centre for Diabetes, Shanghai, China [18]Division of Endocrinology and Metabolism, University of Virginia, Charlottesville, Virginia [19]Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China [20]Department of Endocrinology and Metabolism, China-Japan Friendship Hospital, Beijing, China [21]Blizard Institute, Queen Mary, University of London, London, UK

出处：

DOI：

ISSN：

关键词： type 1 diabetes autoimmune diabetes GAD-Ab IA2-Ab ZnT8-Ab TPO-Ab tTG-Ab 21-OH-Ab

摘要：

Aims To investigate the prevalence of adult-onset autoimmune diabetes (ADM) and predisposition to autoimmune diseases by quantifying serum organ-specific autoantibodies in people with phenotype of type 2 diabetes (T2D). Materials and methods We included a nationally representative sample of 46 239 adults aged >= 20 years from 14 provinces, of whom 4671 had diabetes, plus 1000 control subjects with normal glucose tolerance (NGT). Participants were screened centrally for autoantibodies to glutamic acid decarboxylase (GAD), islet antigen 2 (IA2) and zinc transporter isoform-8 (Znt8) and were defined as having ADM where positive for these antibodies. We then assayed thyroid peroxidase (TPO), tissue transglutaminase (tTG) and 21-hydroxylase (21-OH) autoantibodies in randomly selected participants with ADM and in age-matched, sex-matched and non-ADM controls with T2D plus controls with NGT. Results Post-normalization, the standardized prevalence rate of ADM was 6.0% (95% confidence interval [CI] 5.3-6.8) in initially non-insulin-requiring participants with ADM, corresponding to six million adults in China, in whom adjusted antibody positivity was: TPO autoantibodies 16.3% (95% CI 10.8-21.8), tTG autoantibodies 2.1% (95% CI 0.0-4.2), and 21-OH autoantibodies 1.8% (95% CI -0.2 to 3.8). Those participants with ADM who were GAD autoantibody-positive had high risk of TPO autoantibody positivity (odds ratio [OR] 2.39, P = 0.0031) and tTG autoantibody positivity (OR 6.98, P = 0.027), while those positive for IA2 autoantibodies had a high risk of tTG autoantibody positivity (OR 19.05, P = 0.001). Conclusions A proportion of people with phenotype of T2D in China have ADM, with diabetes-associated autoantibodies, and may be at risk of developing other organ-specific autoimmune diseases; therefore, it may be clinically relevant to consider screening such Chinese populations.

基金：

语种：

被引次数：

WOS：

中科院(CAS)分区：

出版当年[2018]版：

大类 | 1 区

医学

小类 | 1 区内分泌学与代谢

最新[2025]版：

大类 | 2 区医学

小类 | 2 区内分泌学与代谢

JCR分区：

出版当年[2017]版：

Q1 ENDOCRINOLOGY & METABOLISM

最新[2023]版：

Q1 ENDOCRINOLOGY & METABOLISM

影响因子： 最新[2023版] 5.4 最新五年平均[2021-2025] 5.5 出版当年[2017版] 5.98 出版当年五年平均[2013-2017] 5.888 出版前一年[2016版] 6.715 出版后一年[2018版] 6.133

第一作者：

第一作者单位： [1]Department of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, China [2]Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, National Clinical Research Centre for Metabolic Diseases, Changsha, China

共同第一作者：

通讯作者：

通讯机构： [1]Department of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, China [2]Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, National Clinical Research Centre for Metabolic Diseases, Changsha, China [*1]Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

Identification of autoimmune type 1 diabetes and multiple organ-specific autoantibodies in adult-onset non-insulin-requiring diabetes in China: A population-based multicentre nationwide survey

文献详情

相关文献