Cigarette Smoking Is Associated with a Lower Prevalence of Newly Diagnosed Diabetes Screened by OGTT than Non-Smoking in Chinese Men with Normal Weight
单位：[a]Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China[b]Department of Endocrinology and Metabolism, Chinese People's Liberation Army General Hospital, Beijing, China[c]Department of Endocrinology and Metabolism, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China中山大学附属第三医院[d]Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China[e]Department of Endocrinology and Metabolism, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China[f]Department of Endocrinology and Metabolism, Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China[g]Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan, China四川大学华西医院[h]Department of Endocrinology and Metabolism, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China[i]Department of Endocrinology and Metabolism, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China[j]Department of Endocrinology and Metabolism, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China[k]Department of Endocrinology and Metabolism, Fujian Provincial Hospital, Fuzhou, Fujian, China[l]Department of Endocrinology and Metabolism, Qilu Hospital of Shandong University, Jinan, Shandong, China[m]Department of Endocrinology and Metabolism, Peking University First Hospital, Beijing, China[n]Department of Endocrinology and Metabolism, Henan Provincial People's Hospital, Zhengzhou, Henan, China[o]Department of Endocrinology and Metabolism, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China[p]Department of Endocrinology and Metabolism, Second Xiangya Hospital of Central South University, Changsha, Hunan, China[q]Department of Endocrinology and Metabolism, China-Japan Friendship Hospital, Beijing, China
Different studies have produced conflicting results regarding the association between smoking and diabetes mellitus, and detailed analysis of this issue in Chinese males based on nationwide samples is lacking. We explored the association between cigarette smoking and newly-diagnosed diabetes mellitus (NDM) in Chinese males using a population-based case-control analysis; 16,286 male participants without previously diagnosed diabetes were included. Prediabetes and NDM were diagnosed using the oral glucose tolerance test. The cohort included 6,913 non-smokers (42.4%), 1,479 ex-smokers (9.1%) and 7,894 current smokers (48.5%). Age-adjusted glucose concentrations (mmol/L) were significantly lower at fasting and 120 min in current smokers than non-smokers (5.25 vs. 5.30, 6.46 vs. 6.55, respectively, both P < 0.01). After adjustment for demographic and behavioral variables (age, region, alcohol consumption status, physical activity, education, and family history of diabetes), logistic regression revealed significant negative associations between smoking and NDM in males of a normal weight (BMI < 25 kg/m(2): adjusted odds ratio [AOR] = 0.75, P = 0.007; waist circumference < 90 cm: AOR = 0.71, P = 0.001) and males living in southern China (AOR = 0.75, P = 0.009), but not in males who were overweight/obese, males with central obesity, or males living in northern China. Compared to non-smokers, current smokers were less likely to be centrally obese or have elevated BP (AOR: 0.82 and 0.74, both P < 0.05), and heavy smokers (>= 20 pack-years) were less likely to have elevated TG (AOR = 0.84, P = 0.012) among males of a normal weight. There were no significant associations between quitting smoking and metabolic disorders either among males of a normal weight or males who were overweight/obese. In conclusion, smokers have a lower likelihood of NDM than non-smokers among Chinese males with a lower BMI/smaller waist.
基金：
Chinese Medical Association Foundation; Chinese Diabetes Society [07020470055]
第一作者单位：[a]Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Hou X,Qiu J,Chen P,et al.Cigarette Smoking Is Associated with a Lower Prevalence of Newly Diagnosed Diabetes Screened by OGTT than Non-Smoking in Chinese Men with Normal Weight[J].PLOS ONE.2016,11(3):doi:10.1371/journal.pone.0149234.
APA：
Hou, X,Qiu, J,Chen, P,Lu, J,Ma, X...&Jia, W.(2016).Cigarette Smoking Is Associated with a Lower Prevalence of Newly Diagnosed Diabetes Screened by OGTT than Non-Smoking in Chinese Men with Normal Weight.PLOS ONE,11,(3)
MLA：
Hou, X,et al."Cigarette Smoking Is Associated with a Lower Prevalence of Newly Diagnosed Diabetes Screened by OGTT than Non-Smoking in Chinese Men with Normal Weight".PLOS ONE 11..3(2016)
