单位：[1]Department of Ophthalmology, University of California, San Francisco, CA, United States of America,[2]Department of Ophthalmology, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, CA, United States of America,[3]Shenzhen Eye Hospital, Shenzhen Key Laboratory of Ophthalmology, Affiliated Shenzhen Eye Hospital of Jinan University, Shenzhen, China,[4]Department of Ophthalmology, Charoenkrung Pracharak Hospital, Bangkok, Thailand,[5]Department of Ophthalmology, China-Japan Friendship Hospital, Beijing, China,[6]Department of Physiological Nursing, University of California, San Francisco, CA, United States of America
Purpose To compare quantitative changes in macular parameters in diabetic patients detected by two optical coherence tomography angiography (OCTA) instruments. Methods 80 phakic eyes were classified as no diabetes, diabetes without diabetic retinopathy (DR), mild non-proliferative diabetic retinopathy (NPDR), and severe NPDR or proliferative DR (PDR). OCTA was performed using devices from two manufacturers (Zeiss and Heidelberg). Superficial and deeper vascular skeleton density (SVSD, DVSD), superficial and deeper vessel area density (SVAD, DVAD), choriocapillaris flow voids (CCFV), and choroidal flow voids (CFV) were calculated. Inter-device comparisons were performed using the size comparison index (SCI) and the discrepancy index (DI). Results The two devices were inconsistent in SVSD, DVSD, DVAD, CCFV and CFV parameters (allP< 0.05). In addition, the SCI was positive for DVAD (all P < 0.001) and negative for SVSD, DVSD, CCFV and CFV in all groups (allP<0.001), except for DVSD in severe NPDR or PDR. The discrepancy index was not significantly different among groups for SVD, SPD, DVD, DPD and CFV (allP>0.05). The mean DI of CCFV was statistically different between the four groups (P< 0.001). Conclusions The two instruments were largely inconsistent in the measurement of macular parameters relevant to DR. The choice of imaging device can impact OCTA analytics and should be taken into account when drawing conclusions about DR-related changes.
基金：
That Man May See, Inc.; Research to Prevent BlindnessResearch to Prevent Blindness (RPB); National Eye Institute, Core Grant for Vision Research [EY002162]; National Eye InstituteUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Eye Institute (NEI) [1R01EY024004]
第一作者单位：[1]Department of Ophthalmology, University of California, San Francisco, CA, United States of America,[2]Department of Ophthalmology, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, CA, United States of America,[3]Shenzhen Eye Hospital, Shenzhen Key Laboratory of Ophthalmology, Affiliated Shenzhen Eye Hospital of Jinan University, Shenzhen, China,
通讯作者：
通讯机构：[1]Department of Ophthalmology, University of California, San Francisco, CA, United States of America,[2]Department of Ophthalmology, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, CA, United States of America,
推荐引用方式(GB/T 7714)：
Yi Chen,Sawarin Laotaweerungsawat,Tong Zhao,et al.Discordant vascular parameter measurements in diabetic and non-diabetic eyes detected by different optical coherence tomography angiography devices[J].PLOS ONE.2020,15(6):doi:10.1371/journal.pone.0234664.
APA：
Yi Chen,Sawarin Laotaweerungsawat,Tong Zhao,Zeeshan Haq,Xiuyun Liu...&Jay M. Stewart.(2020).Discordant vascular parameter measurements in diabetic and non-diabetic eyes detected by different optical coherence tomography angiography devices.PLOS ONE,15,(6)
MLA：
Yi Chen,et al."Discordant vascular parameter measurements in diabetic and non-diabetic eyes detected by different optical coherence tomography angiography devices".PLOS ONE 15..6(2020)
