Clinicopathological features and prognostic validity of the European Neuroendocrine Tumor Society (ENETS) and American Joint Committee on Cancer (AJCC) 8th staging systems in colonic neuroendocrine neoplasms
单位：[1]Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.院本部内科消化内科中山大学附属第一医院[2]Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.[3]Department of Gastrointestinal Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.[4]Department of Gastric Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.[5]Division of Abdominal Cancer, Cancer Center, West China Hospital of Sichuan University, Chengdu, China.四川大学华西医院[6]Department of General Surgery, Guangdong General Hospital, Guangzhou, China.广东省人民医院[7]Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.[8]Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing, China.[9]Department of Colorectal Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China.[10]Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.华中科技大学同济医学院附属协和医院[11]Division of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.华中科技大学同济医学院附属协和医院[12]Department of Gastroenteropancreatic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.中山大学附属第二医院[13]Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Purpose This study aimed to investigate the characteristics of colonic neuroendocrine neoplasms (NENs) and to validate the prognostic value of the European Neuroendocrine Tumor Society (ENETS) and American Joint Committee on Cancer (AJCC) 8th staging systems. Methods A total of 167 and 1248 patients with colonic NENs from 12 medical centers across China and from the Surveillance, Epidemiology, and End Results (SEER) cancer registry in the United States, respectively, were reviewed. Patients were staged according to the ENETS and AJCC 8th staging systems. Results Clinicopathological features of colonic NENs in the Chinese cohort and SEER cohort were significantly distinct. In both the Chinese cohort and the SEER cohort, colonic neuroendocrine carcinoma (NEC) and mixed adeno-neuroendocrine carcinoma (MANEC) were more frequent in the midgut than in the hindgut. Tumors originating from the midgut tended to be larger and at a more advanced stage than those from the hindgut. The AJCC 8th staging system and the ENETS system appeared to have similar prognostic ability for colonic NEC/MANEC. Conclusions Our study revealed that tumors originating from the midgut and the hindgut shared different clinicopathological features. The AJCC 8th staging system and the ENETS system appeared to have similar prognostic ability for colonic NEC/MANEC.
基金：
Foundation of Guangzhou Science and Technology Plan [201804010078]
第一作者单位：[1]Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.[2]Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.[3]Department of Gastrointestinal Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.[*1]Department of Gastroenterology, The First Affiliated Hospital, Sun Yat‐sen University, No.58 Zhongshan II Road, Yuexiu District, Guangzhou, China 510080.[*2]Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, No.324 Jingwu Road, Huaiyin District, Jinan, China 250021.[*3]Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, No.52 Fucheng Road, Haidian District, Beijing, China 100142.
推荐引用方式(GB/T 7714)：
Zhang Yu,Shang Liang,Zhang Pan-Pan,et al.Clinicopathological features and prognostic validity of the European Neuroendocrine Tumor Society (ENETS) and American Joint Committee on Cancer (AJCC) 8th staging systems in colonic neuroendocrine neoplasms[J].CANCER MEDICINE.2019,8(11):5000-5011.doi:10.1002/cam4.2370.
APA：
Zhang Yu,Shang Liang,Zhang Pan-Pan,Chen Luo-Hai,Wang Wei...&Chen Jie.(2019).Clinicopathological features and prognostic validity of the European Neuroendocrine Tumor Society (ENETS) and American Joint Committee on Cancer (AJCC) 8th staging systems in colonic neuroendocrine neoplasms.CANCER MEDICINE,8,(11)
MLA：
Zhang Yu,et al."Clinicopathological features and prognostic validity of the European Neuroendocrine Tumor Society (ENETS) and American Joint Committee on Cancer (AJCC) 8th staging systems in colonic neuroendocrine neoplasms".CANCER MEDICINE 8..11(2019):5000-5011
