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A multicenter RCT of noninvasive ventilation in pneumonia-induced early mild acute respiratory distress syndrome

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收录情况： ◇ SCIE

作者：
He, Hangyong[1,27] * ; Sun, Bing[1,27] ; Liang, Lirong[1,27] ; Li, Yanming[2,28] ; Wang, He[2,28] ; Wei, Luqing[3,29] ; Li, Guofeng[3,29] ; Guo, Shuliang[4,30] ; Duan, Jun[4,30] ; Li, Yuping[5,31] ; Zhou, Ying[5,31] ; Chen, Yusheng[32] ; Li, Hongru[6,32] ; Yang, Jingping[7,33] ; Xu, Xiyuan[7,33] ; Song, Liqiang[8,34] ; Chen, Jie[8,34] ; Bao, Yong[9,35] ; Chen, Feng[9,35] ; Wang, Ping[10,36] ; Ji, Lixi[10,36] ; Zhang, Yongxiang[11,37] ; Ding, Yanyan[11,37] ; Chen, Liangan[12,38] ; Wang, Ying[12,38] ; Yang, Lan[13,39] ; Yang, Tian[13,39] ; Weng, Heng[14,40] ; Li, Hongyan[14,40] ; Wang, Daoxin[15,41] ; Tong, Jin[15,41] ; Sun, Yongchang[16,42] ; Li, Ran[16,42] ; Jin, Faguang[17,43] ; Li, Chunmei[17,43] ; He, Bei[18,44] ; Sun, Lina[18,44] ; Wang, Changzheng[19,45] ; Hu, Mingdong[19,45] ; Yang, Xiaohong[20,46] ; Luo, Qin[20,46] ; Zhang, Jin[21,47] ; Tan, Hai[21,47] ; Wang, Chen[22,23,24,25,26,48] ; Liu, Bin[29] ; Hong, Rujun[32] ; Yao, Xiujuan[32] ; Lu, Fengfeng[32] ; Wang, Hui[33] ; Wang, Ling[33] ; Tian, Hongjun[33] ; Wu, Yunfu[34] ; Huang, Xiaofang[36] ; Sun, Min[36] ; Liang, Zhixin[38] ; Lin, Xu[40] ; Deng, Wang[41] ; Xu, Jie[42] ; Nan, Yandong[43] ; Shen, Ning[44] ; Li, Mei[46] ;
单位： [1]Capital Med Univ, Beijing Chao Yang Hosp,Beijing Inst Resp Med, Beijing Engn Res Ctr Diag & Treatment Pulm & Crit, Beijing Key Lab Resp & Pulm Circulat Disorders, 8 Gongren Tiyuchang Nanlu, Beijing 100020, Peoples R China [2]Beijing Hosp, Dept Resp & Crit Care Med, Beijing, Peoples R China [3]Chinese Armed Police Forces, Dept Resp & Crit Care Med, Affiliated Hosp Logist, Tianjin, Peoples R China [4]Chongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Chongqing, Peoples R China [5]Wenzhou Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China [6]Fujian Prov Hosp, Dept Pulm, Fuzhou, Fujian, Peoples R China [7]Inner Mongolia Med Coll, Affiliated Hosp 3, Dept Resp & Crit Care Med, Baotou, Inner Mongolia, Peoples R China [8]Fourth Mil Med Univ, Xijing Hosp, Dept Pulm, Xian, Shanxi, Peoples R China [9]Third Peoples Hosp Chengdu, Dept Pulm, Chengdu, Sichuan, Peoples R China [10]Chengdu Fifth Peoples Hosp, Dept Crit Care Med, Chengdu, Sichuan, Peoples R China [11]Peoples Hosp Beijing Daxing Dist, Dept Resp Med, Beijing, Peoples R China [12]Chinese Peoples Liberat Army Gen Hosp, Dept Pulm & Crit Care Med, Beijing, Peoples R China [13]Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Xian, Shanxi, Peoples R China [14]Lung Dis Hosp Fujian Fuzhou, Dept Pulm, Fuzhou, Fujian, Peoples R China [15]Chongqing Med Univ, Affiliated Hosp 2, Dept Pulm, Chongqing, Peoples R China [16]Beijing Tongren Hosp, Dept Pulm, Beijing, Peoples R China [17]Fourth Mil Med Univ, Tangdu Hosp, Dept Resp & Crit Care Med, Xian, Shanxi, Peoples R China [18]Peking Univ, Hosp 3, Dept Pulm, Beijing, Peoples R China [19]Army Med Univ, Xinqiao Hosp, Dept Pulm, Chongqing, Peoples R China [20]Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Resp & Crit Care Med, Urumqi, Xinjiang Uygur, Peoples R China [21]Ningxia Med Univ, Gen Hosp, Dept Resp & Crit Care Med, Yinchuan, Ningxia Provinc, Peoples R China [22]Chinese Acad Med Sci, Beijing, Peoples R China [23]Peking Union Med Coll, Beijing, Peoples R China [24]China Japan Friendship Hosp, Ctr Resp Med, Dept Pulm & Crit Care Med, 2 Yinghua East Rd, Beijing 100029, Peoples R China [25]Capital Med Univ, Dept Resp Med, Beijing, Peoples R China [26]Natl Clin Res Ctr Resp Dis, Beijing, Peoples R China [27]Beijing Chao Yang Hosp, Beijing Inst Resp Med, Beijing, Peoples R China [28]Beijing Hosp, Beijing, Peoples R China [29]Chinese Armed Police Forces, Logist Coll, Affiliated Hosp, Tianjin, Peoples R China [30]Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China [31]Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou, Peoples R China [32]Fujian Prov Hosp, Fuzhou, Fujian, Peoples R China [33]Inner Mongolia Med Coll, Affiliated Hosp 3, Hohhot, Peoples R China [34]Forth Mil Med Univ, Xijing Hosp, Xian, Shaanxi, Peoples R China [35]Third Peoples Hosp Chengdu, Chengdu, Sichuan, Peoples R China [36]Chengdu Fifth Peoples Hosp, Chengdu, Sichuan, Peoples R China [37]Peoples Hosp Beijing Daxing Dist, Beijing, Peoples R China [38]Chinese Peoples Liberat Army Gen Hosp, Beijing, Peoples R China [39]Xi An Jiao Tong Univ, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China [40]Lung Dis Hosp, Fuzhou, Fujian, Peoples R China [41]Chongqing Med Univ, Affiliated Hosp 2, Chongqing, Peoples R China [42]Beijing Tongren Hosp, Beijing, Peoples R China [43]Fourth Mil Med Univ, Tangdu Hosp, Xian, Shaanxi, Peoples R China [44]Peking Univ, Hosp 3, Beijing, Peoples R China [45]Army Med Univ, Xinqiao Hosp, Chongqing, Peoples R China [46]Peoples Hosp Xinjiang Uygur Autonomous Reg, Urumqi, Peoples R China [47]Ningxia Med Univ, Gen Hosp, Yinchuan, Ningxia Provinc, Peoples R China [48]China Japan Friendship Hosp, Ctr Resp Med, Dept Pulm & Crit Care Med, Beijing, Peoples R China
出处：
DOI： 10.1186/s13054-019-2575-6
ISSN：

关键词： Acute respiratory distress syndrome (ARDS) Noninvasive ventilation (NIV) Pneumonia

摘要：
Rationale Our pilot study suggested that noninvasive ventilation (NIV) reduced the need for intubation compared with conventional administration of oxygen on patients with "early" stage of mild acute respiratory distress syndrome (ARDS, PaO2/FIO2 between 200 and 300). Objectives To evaluate whether early NIV can reduce the need for invasive ventilation in patients with pneumonia-induced early mild ARDS. Methods Prospective, multicenter, randomized controlled trial (RCT) of NIV compared with conventional administration of oxygen through a Venturi mask. Primary outcome included the numbers of patients who met the intubation criteria. Results Two hundred subjects were randomized to NIV (n = 102) or control (n = 98) groups from 21 centers. Baseline characteristics were similar in the two groups. In the NIV group, PaO2/FIO2 became significantly higher than in the control group at 2 h after randomization and remained stable for the first 72 h. NIV did not decrease the proportion of patients requiring intubation than in the control group (11/102 vs. 9/98, 10.8% vs. 9.2%, p = 0.706). The ICU mortality was similar in the two groups (7/102 vs. 7/98, 4.9% vs. 3.1%, p = 0.721). Multivariate analysis showed minute ventilation greater than 11 L/min at 48 h was the independent risk factor for NIV failure (OR, 1.176 [95% CI, 1.005-1.379], p = 0.043). Conclusions Treatment with NIV did not reduce the need for intubation among patients with pneumonia-induced early mild ARDS, despite the improved PaO2/FIO2 observed with NIV compared with standard oxygen therapy. High minute ventilation may predict NIV failure.

基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81490534]; National Science and Technology Pillar Program during the 12th Five-year Plan [2012BAI05B02]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 2 区 医学
小类 | 3 区 危重病医学
最新[2025]版：
大类 | 1 区 医学
小类 | 2 区 危重病医学
JCR分区：
出版当年[2017]版：
Q1 CRITICAL CARE MEDICINE
最新[2023]版：
Q1 CRITICAL CARE MEDICINE

影响因子： 最新[2023版] 最新五年平均[2021-2025] 出版当年[2017版] 出版当年五年平均[2013-2017] 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者单位： [1]Capital Med Univ, Beijing Chao Yang Hosp,Beijing Inst Resp Med, Beijing Engn Res Ctr Diag & Treatment Pulm & Crit, Beijing Key Lab Resp & Pulm Circulat Disorders, 8 Gongren Tiyuchang Nanlu, Beijing 100020, Peoples R China [27]Beijing Chao Yang Hosp, Beijing Inst Resp Med, Beijing, Peoples R China
通讯作者：
通讯机构： [22]Chinese Acad Med Sci, Beijing, Peoples R China [23]Peking Union Med Coll, Beijing, Peoples R China [24]China Japan Friendship Hosp, Ctr Resp Med, Dept Pulm & Crit Care Med, 2 Yinghua East Rd, Beijing 100029, Peoples R China [25]Capital Med Univ, Dept Resp Med, Beijing, Peoples R China [26]Natl Clin Res Ctr Resp Dis, Beijing, Peoples R China [48]China Japan Friendship Hosp, Ctr Resp Med, Dept Pulm & Crit Care Med, Beijing, Peoples R China
推荐引用方式(GB/T 7714)：
He Hangyong,Sun Bing,Liang Lirong,et al.A multicenter RCT of noninvasive ventilation in pneumonia-induced early mild acute respiratory distress syndrome[J].CRITICAL CARE.2019,23(1):doi:10.1186/s13054-019-2575-6.
APA：
He, Hangyong,Sun, Bing,Liang, Lirong,Li, Yanming,Wang, He...&Li, Mei.(2019).A multicenter RCT of noninvasive ventilation in pneumonia-induced early mild acute respiratory distress syndrome.CRITICAL CARE,23,(1)
MLA：
He, Hangyong,et al."A multicenter RCT of noninvasive ventilation in pneumonia-induced early mild acute respiratory distress syndrome".CRITICAL CARE 23..1(2019)

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