单位：[1]Department of Infectious Disease, Center for Liver Disease, Peking University First Hospital, Beijing, China[2]StateKey Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and VaccineDevelopment in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, China[3]Department ofInfectious Disease, China-Japan Friendship Hospital, Beijing, China[4]Department of Infectious Disease, The ThirdAffiliated Hospital Sun Yat-Sen University, Guangzhou, Guangdong, China[5]Department of Infectious Diseases, SouthWest Hospital affiliated to Third Military Medical University, Chongqing, China[6]Department of Infectious Diseases,Second Affiliated Hospital of Chongqing Medical University, Chongqing, China[7]Department of Infectious Diseases,Rui Jin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China[8]Department of InfectiousDiseases, The People’s Hospital of Guang Xi Zhuang Autonomous Region, Nanning, Guangxi, China[9]Department ofInfectious Diseases, The People’s Hospital of He Nan Province, Zhengzhou, Henan, China[10]Department of InfectiousDiseases, Di Tan Hospital affiliated to Capital Medical University, Beijing, China[11]Department of Infectious Diseases,Xinxiang Medical University Third Hospital, Xinxiang, Henan, China[12]Department of Infectious Diseases, Yan taiCity Hospital for Infectious Disease, Yan tai, Shandong, China[13]Department of Infectious Diseases, Shenyang SixthPeople’s Hospital, Shenyang, Liaoning, China[14]Collaborative Innovation Center for Diagnosis and Treatment ofInfectious Diseases, Zhejiang University, Hangzhou, Zhejiang, China
Our previous studies unexpectedly indicated that the level of serum hepatitis B core antibody (antiHBc) was positively correlated with the serum alanine aminotransferase (ALT) level. The aim of this study was to determine whether anti-HBc could serve as a potential biomarker for the detection of liver inflammation in chronic hepatitis B (CHB) patients, especially in patients with normal ALT levels. Serum anti-HBc levels were quantified in 655 treatment-naive CHB patients, including 45 patients who underwent two liver biopsies (baseline phase and the 78(th) weeks of antiviral-treatment). Serum antiHBc levels increased significantly along with the increasing histology activity index (HAI) score. After antiviral-treatment, patients with HAI score reduction had significant decline in serum anti-HBc level. Multivariate analysis showed that anti-HBc was independently associated with moderate-to-severe hepatic inflammation in patients with normal ALT level. Furthermore, serum anti-HBc showed a high diagnostic accuracy for predicting moderate-to-severe inflammation in both hepatitis B e antigen (HBeAg)-positive and HBeAg-negative CHB patients with normal ALT levels (area under the curve, AUC=0.87 and 0.75; respectively). Thus, anti-HBc may be a strong indicator for assessing the hepatic inflammatory degree and used for antiviral treatment decisions in CHB patients with normal ALT levels.
基金：
China Mega-Project for Infectious Diseases [2013ZX10002005, 2012ZX10002006, 2013ZX10002004, 2012ZX10005005]; Project of Beijing Science and Technology Committee [D121100003912002]; HRS through IP3R-IP3 [F15-139-9-08]; National Key Clinical Program of the Ministry of Health
第一作者单位：[1]Department of Infectious Disease, Center for Liver Disease, Peking University First Hospital, Beijing, China
通讯作者：
通讯机构：[1]Department of Infectious Disease, Center for Liver Disease, Peking University First Hospital, Beijing, China[14]Collaborative Innovation Center for Diagnosis and Treatment ofInfectious Diseases, Zhejiang University, Hangzhou, Zhejiang, China
推荐引用方式(GB/T 7714)：
Jiyuan Zhou,Liuwei Song,Hong Zhao,et al.Serum hepatitis B core antibody as a biomarker of hepatic inflammation in chronic hepatitis B patients with normal alanine aminotransferase[J].SCIENTIFIC REPORTS.2017,7:doi:10.1038/s41598-017-03102-3.
APA：
Jiyuan Zhou,Liuwei Song,Hong Zhao,Linlin Yan,Anlin Ma...&Guiqiang Wang.(2017).Serum hepatitis B core antibody as a biomarker of hepatic inflammation in chronic hepatitis B patients with normal alanine aminotransferase.SCIENTIFIC REPORTS,7,
MLA：
Jiyuan Zhou,et al."Serum hepatitis B core antibody as a biomarker of hepatic inflammation in chronic hepatitis B patients with normal alanine aminotransferase".SCIENTIFIC REPORTS 7.(2017)
