单位：[1]Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China[2]Department of Endocrinology and Metabolism, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China[3]Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China四川大学华西医院[4]Department of Endocrinology and Metabolism, China-Japan Friendship Hospital, Beijing, China[5]Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Harbin, China[6]Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated First People's Hospital, Shanghai, China[7]Department of Endocrinology and Metabolism, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China院本部南沙医院内科内分泌内科内科内分泌内科中山大学附属第一医院[8]Department of Endocrinology and Metabolism, Fudan University Affiliated Zhongshan Hospital, Shanghai, China[9]Department of Endocrinology and Metabolism, The First People's Hospital of Foshan, Foshan, China[10]Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Objective: Although the association between alanine aminotransferase (ALT) levels and risk of type 2 diabetes is well-studied, the effects of slightly increased ALT levels within the normal range on the temporal normal glucose profile remains poorly understood. Methods: A total of 322 Chinese subjects without impaired glucose tolerance or previous diagnoses of diabetes were recruited for study from 10 hospitals in urban areas across China. All subjects wore a continuous glucose monitoring (CGM) system for three consecutive days. The diurnal (06:00-20:00) and nocturnal (20:00-06:00) mean blood glucose (MBG) levels were calculated. Subjects were stratified by ALT quartile level and correlation analyses were performed. Results: The median ALT level was 17 IU/L, and subjects with ALT >= 17 IU/L had higher nocturnal MBG level than those with ALT < 17 IU/L (P<0.05). Nocturnal MBG was positively correlated with ALT levels (Pearson correlation analysis: r = 0.187, P = 0.001), and the correlation remained significant after correction for the homeostatic model assessment of insulin resistance index (HOMA-IR) (r = 0.105, P = 0.041). No correlations were found between diurnal MBG and ALT, and nocturnal or diurnal MBG and aspartate aminotransferase or gamma-glutamyltransferase (all, P>0.05). Multivariate stepwise regression analysis of elevated nocturnal MBG identified increased HOMA-IR, elevated ALT levels, and decreased homeostatic model assessment of beta-cell function as independent factors (all, P<0.05). Conclusions: Mildly elevated ALT levels, within the normal range, are associated with unfavorable nocturnal glucose profiles in Chinese subjects with normal glucose regulation.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81100590]; Shanghai Rising-Star Program [12QA1402500]; Shanghai United Developing Technology Project of Municipal Hospitals [SHDC12010115]; Shanghai Medical Program for Outstanding Young Talent [XYQ2011013]
第一作者单位：[1]Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China
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推荐引用方式(GB/T 7714)：
Jian Zhou,Yifei Mo,Hong Li,et al.Alanine Aminotransferase Is Associated with an Adverse Nocturnal Blood Glucose Profile in Individuals with Normal Glucose Regulation[J].PLOS ONE.2013,8(2):doi:10.1371/journal.pone.0056072.
APA：
Jian Zhou,Yifei Mo,Hong Li,Xingwu Ran,Wenying Yang...&Weiping Jia.(2013).Alanine Aminotransferase Is Associated with an Adverse Nocturnal Blood Glucose Profile in Individuals with Normal Glucose Regulation.PLOS ONE,8,(2)
MLA：
Jian Zhou,et al."Alanine Aminotransferase Is Associated with an Adverse Nocturnal Blood Glucose Profile in Individuals with Normal Glucose Regulation".PLOS ONE 8..2(2013)
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