单位：[a]National Integrated Traditional and Western Medicine Center for Cardivascular Disease, China-Japan Friendship Hospital, Beijing 100101, China[b]Department of Psychiatric-Neuroimaging-Genetics Laboratory (PNG_Lab), Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang Province 325000, China[c]PNGC-Lab, Tianjin Mental Health Centre, Tianjin Anding Hospital, Tianjin, 300222, China[d]Department of Psychiatry, First Hospital of Shanxi Medical University, Tainyuan, 030001, China[e]Department of Psychiatry, School of Mental Health, Jining Medical University, Jining, Shandong Province 272100, China[f]Department of Pharmacology, The first Hospital of Hebei Medical University, Shijiazhuang, Hebei Province 37000,China[g]Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
Depression is a highly prevalent risk factor for both the onset of cardiovascular disease (CVD) and the mortality of CVD patients, and people suffering from CVD are more likely to develop depression than healthy individuals. The aim of this review is to summarize recent findings regarding the underlying relationship between CVD and depression. Literature search and review were conducted using PubMed, Google Scholar, Wanfang Med Online, and Baidu Scholar databases. CVD and depression are intimately related and researchers from around the world have proposed and validated various mechanisms that may potentially explain the comorbidity of CVD and depression. Recent studies have suggested that depression and CVD may manifest as two distinct clinical conditions in two different organs, the brain and the heart, respectively, but may also be linked by shared mechanisms. Of these, inflammation involving the immune system is thought to be a common mechanism of depression and heart disease, with specific inflammatory cytokines or pathways being potential targets for the prevention and treatment of the concurrent diseases. Therefore, inflammation may play an important role in bridging the link between depression and CVD, a finding that can have important clinical implications for the prevention and early intervention of these conditions.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81871052, 81801679, 81571319]; Natural Science Foundation of Tianjin, ChinaNatural Science Foundation of Tianjin [17JCZDJC35700]; Tianjin Health Bureau Foundation [2014KR02]; National Key Research and Development Program of China [2016YFC1307004]; Shanxi Science and Technology Innovation Training Team's Multidisciplinary Team for Cognitive Impairment [201705D131027]; Zhejiang Public Welfare Fund Project [LGF18H090002]; Wenzhou Science and Technology Bureau [ZS2017011]
第一作者单位：[a]National Integrated Traditional and Western Medicine Center for Cardivascular Disease, China-Japan Friendship Hospital, Beijing 100101, China
共同第一作者：
通讯作者：
通讯机构：[b]Department of Psychiatric-Neuroimaging-Genetics Laboratory (PNG_Lab), Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang Province 325000, China[d]Department of Psychiatry, First Hospital of Shanxi Medical University, Tainyuan, 030001, China[e]Department of Psychiatry, School of Mental Health, Jining Medical University, Jining, Shandong Province 272100, China[g]Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
推荐引用方式(GB/T 7714)：
Shao Mingjing,Lin Xiaodong,Jiang Deguo,et al.Depression and cardiovascular disease: Shared molecular mechanisms and clinical implications[J].PSYCHIATRY RESEARCH.2020,285:doi:10.1016/j.psychres.2020.112802.
APA：
Shao Mingjing,Lin Xiaodong,Jiang Deguo,Tian Hongjun,Xu Yong...&Zhuo Chuanjun.(2020).Depression and cardiovascular disease: Shared molecular mechanisms and clinical implications.PSYCHIATRY RESEARCH,285,
MLA：
Shao Mingjing,et al."Depression and cardiovascular disease: Shared molecular mechanisms and clinical implications".PSYCHIATRY RESEARCH 285.(2020)
