单位：[1]Clinical Institute of China-Japan Friendship Hospital, Graduate School of Peking Union Medical College[2]Department of Dermatology and Venerology, China-Japan Friendship Hospital, Beijing, China
Psoriasis is a chronic skin inflammatory disorder, the immune mechanism of which has been profoundly elucidated in the past few years. The dominance of the interleukin (IL)-23/IL-17 axis is a significant breakthrough in the understanding of the pathogenesis of psoriasis, and treatment targeting IL-23 and IL-17 has successfully benefited patients with the disease. The skin contains a complex network of dendritic cells (DC) mainly composed of epidermal Langerhans cells, bone marrow-derived dermal conventional DC, plasmacytoid DC and inflammatory DC. As the prominent cellular source of alpha-interferon, tumor necrosis factor-alpha, IL-12 and IL-23, DC play a pivotal role in psoriasis. Thus, targeting pathogenic DC subsets is a valid strategy for alleviating and preventing psoriasis and other DC-derived diseases. In this review, we survey the known role of DC in this disease.
第一作者单位：[1]Clinical Institute of China-Japan Friendship Hospital, Graduate School of Peking Union Medical College[2]Department of Dermatology and Venerology, China-Japan Friendship Hospital, Beijing, China
通讯作者：
通讯机构：[1]Clinical Institute of China-Japan Friendship Hospital, Graduate School of Peking Union Medical College[2]Department of Dermatology and Venerology, China-Japan Friendship Hospital, Beijing, China[*1]Department of Dermatology and Venerology, China-Japan Friendship Hospital, 2 Yinghua East Street, Chaoyang District, Beijing 100029, China
推荐引用方式(GB/T 7714)：
Wang Ao,Bai YanPing.Dendritic cells: The driver of psoriasis[J].JOURNAL of DERMATOLOGY.2020,47(2):104-113.doi:10.1111/1346-8138.15184.
APA：
Wang, Ao&Bai, YanPing.(2020).Dendritic cells: The driver of psoriasis.JOURNAL of DERMATOLOGY,47,(2)
MLA：
Wang, Ao,et al."Dendritic cells: The driver of psoriasis".JOURNAL of DERMATOLOGY 47..2(2020):104-113
