Objective To investigate the diagnostic utility of fine needle aspiration (FNA) smear, cell block (CB), flow cytometry (FC) and tuberculosis polymerase chain reaction (Tb-PCR) analysis for Kikuchi's disease (KD). Methods A total of 173 FNA biopsy samples were collected using a Youyi aspirator. KD was diagnosed by FNA smear, with or without, CB, FC and Tb-PCR. Results Out of 173 patients, 131 (75.7%) were female and 126 (72.8%) aged 21-40 years. Of these, 171 patients (98.8%) presented with painful enlarged cervical lymph nodes. All cytological samples identified intracellular apoptotic debris embedded in the cytoplasm of crescentic and phagocytic macrophages. In 24 cell-blocks (CBs), clusters of CD123 positive plasmacytoid monocytes were observed in KD. FC and CBs showed non-specific lymphoid hyperplasia in nine cases with suspicious lymphoma. Tb-PCR was negative in five cases with suspicion of tuberculosis. Conclusions In summary, FNA biopsy is a fast, reliable, and relatively inexpensive diagnosis tool for KD. CB preparation is an important adjunct method for the diagnosis of KD.
第一作者单位：[1]Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing, China[*1]Department of Pathology,Beijing Friendship Hospital, Capital Medical University, Beijing, China.
推荐引用方式(GB/T 7714)：
Miao Wang,Xiaomeng Yu,Yan Yang.Diagnosing Kikuchi's disease on fine needle aspiration biopsy[J].CYTOPATHOLOGY.2020,31(1):22-25.doi:10.1111/cyt.12754.
APA：
Miao Wang,Xiaomeng Yu&Yan Yang.(2020).Diagnosing Kikuchi's disease on fine needle aspiration biopsy.CYTOPATHOLOGY,31,(1)
MLA：
Miao Wang,et al."Diagnosing Kikuchi's disease on fine needle aspiration biopsy".CYTOPATHOLOGY 31..1(2020):22-25
