单位：[1]Beijing Key Laboratory for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Sciences, China- Japan Friendship Hospital, Beijing 100029, China [2]Beijing University of Chinese Medicine, Beijing 100029, China [3]Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA [4]Department of Nephrology, Guang’anmen Hospital of China Academy of Traditional Chinese Medical Sciences, Beijing 100053, China [5]Beijing Key Laboratory of Diabetes Research and Care, Center for Endocrine Metabolism and Immune Diseases, Luhe Hospital, Capital Medical University, Beijing 101149, China首都医科大学附属同仁医院
Podocyte injury is an important pathogenesis step causing proteinuric kidney diseases such as diabetic kidney disease (DKD). Actin cytoskeleton rearrangement in podocyte induced by multiple pathogenic factors is believed to be the key process resulting in glomerular injury. Many studies have recently shown that transient receptor potential canonical channel 6 (TRPC6) in podocyte plays a critical role in the development and progression of proteinuric kidney disease by regulating its actin cytoskeleton rearrangement. This review is aimed at summarizing the role of TRPC6 on DKD by regulating the podocyte actin cytoskeleton rearrangement, thereby help further broaden our views and understanding on the mechanism of DKD and provide a theoretic basis for exploring new therapeutic targets for DKD patients.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81620108031, 81973627]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区医学
小类|3 区医学：研究与实验4 区内分泌学与代谢
最新[2025]版：
大类|3 区医学
小类|3 区内分泌学与代谢3 区医学：研究与实验
JCR分区：
出版当年[2018]版：
Q2MEDICINE, RESEARCH & EXPERIMENTALQ3ENDOCRINOLOGY & METABOLISM
最新[2023]版：
Q2ENDOCRINOLOGY & METABOLISMQ2MEDICINE, RESEARCH & EXPERIMENTAL
第一作者单位：[1]Beijing Key Laboratory for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Sciences, China- Japan Friendship Hospital, Beijing 100029, China [2]Beijing University of Chinese Medicine, Beijing 100029, China
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Qian,Tian Xuefei,Wang Yuyang,et al.Role of Transient Receptor Potential Canonical Channel 6 (TRPC6) in Diabetic Kidney Disease by Regulating Podocyte Actin Cytoskeleton Rearrangement[J].JOURNAL of DIABETES RESEARCH.2020,2020:doi:10.1155/2020/6897390.
APA：
Wang, Qian,Tian, Xuefei,Wang, Yuyang,Wang, Yan,Li, Jialin...&Li, Ping.(2020).Role of Transient Receptor Potential Canonical Channel 6 (TRPC6) in Diabetic Kidney Disease by Regulating Podocyte Actin Cytoskeleton Rearrangement.JOURNAL of DIABETES RESEARCH,2020,
MLA：
Wang, Qian,et al."Role of Transient Receptor Potential Canonical Channel 6 (TRPC6) in Diabetic Kidney Disease by Regulating Podocyte Actin Cytoskeleton Rearrangement".JOURNAL of DIABETES RESEARCH 2020.(2020)
