单位：[1]Department of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, 510260 Guangzhou, China [2]Translational Medicine Center, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, 510260 Guangzhou, China [3]Translational Medicine Center, Huaihe Hospital of Henan University, 475000 Kaifeng, China [4]Department of Hematology, Huaihe Hospital of Henan University, 475000 Kaifeng, China [5]Department of Operations and Information Management, China- Japan Friendship Hospital, 100029 Beijing, China
Multiple myeloma (MM) is a plasma cell malignancy. The minichromosome maintenance (MCM) family involve in DNA replication and is vital in limiting replication in cell cycle. The prognostic role of MCMs in MM is still unclear. We took four independent GEO datasets to analyze the relationship between the expression of MCMs and myeloma progression and survival. The expression of MCMs showed an upward trend with myeloma progression in 205 patients. High MCM2/3/4/6/8 expression was associated with both poor EFS and OS (all p < 0.050). Multivariate analysis demonstrated that high MCM2 expression, B2M, and LDH were independent risk factors. Moreover, the combination of MCM2/B2M and MCM2/LDH was a better tool in prognostication. In conclusion, high MCM2 expression is an independent adverse prognostic factor and could be used as a prognostic biomarker in MM.
基金：
Xinjiang Joint Fund of National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [U1903117]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81500118]
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2019]版：
大类|2 区医学
小类|2 区生物工程与应用微生物2 区遗传学2 区医学：研究与实验3 区肿瘤学
最新[2025]版：
大类|3 区医学
小类|3 区生物工程与应用微生物3 区遗传学3 区医学：研究与实验4 区肿瘤学
JCR分区：
出版当年[2018]版：
Q1GENETICS & HEREDITYQ1BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ1MEDICINE, RESEARCH & EXPERIMENTALQ2ONCOLOGY
最新[2023]版：
Q1BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ1GENETICS & HEREDITYQ1MEDICINE, RESEARCH & EXPERIMENTALQ1ONCOLOGY
第一作者单位：[1]Department of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, 510260 Guangzhou, China [2]Translational Medicine Center, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, 510260 Guangzhou, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, 510260 Guangzhou, China [2]Translational Medicine Center, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, 510260 Guangzhou, China [3]Translational Medicine Center, Huaihe Hospital of Henan University, 475000 Kaifeng, China [4]Department of Hematology, Huaihe Hospital of Henan University, 475000 Kaifeng, China
推荐引用方式(GB/T 7714)：
Liang Quan,Tingting Qian,Longzhen Cui,et al.Prognostic role of minichromosome maintenance family in multiple myeloma[J].CANCER GENE THERAPY.2020,27(10-11):819-829.doi:10.1038/s41417-020-0162-2.
APA：
Liang Quan,Tingting Qian,Longzhen Cui,Yan Liu,Lin Fu&Chaozeng Si.(2020).Prognostic role of minichromosome maintenance family in multiple myeloma.CANCER GENE THERAPY,27,(10-11)
MLA：
Liang Quan,et al."Prognostic role of minichromosome maintenance family in multiple myeloma".CANCER GENE THERAPY 27..10-11(2020):819-829
