单位：[1]Department of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China[2]Translational Medicine Center, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China[3]Translational Medicine Center, Huaihe Hospital of Henan University, Kaifeng 475000, China[4]Department of Hematology, Huaihe Hospital of Henan University, Kaifeng 475000, China[5]Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands[6]Department of Biomedical Sciences, University of Sassari, Sassari, Italy[7]Department of Hematology, The First Affiliated Hospital of Shihezi University, Shihezi 832000, China[8]Department of Biomedical Engineering, Chinese PLA General Hospital, Beijing 100853, China[9]Department of Operations and Information Management, China- Japan Friendship Hospital, Beijing 100029, China
The prognosis role of CCT3 in MM and the possible pathways it involved were studied in our research. By analyzing ten independent datasets (including 48 healthy donors, 2220 MM, 73 MGUS, and 6 PCL), CCT3 was found to express higher in MM than healthy donors, and the expression level was gradually increased from MGUS, SMM, MM to PCL (all P < 0.01). By analyzing three independent datasets (GSE24080, GSE2658, and GSE4204), we found that CCT3 was a significant indicator of poor prognosis (all P < 0.01). KEGG and GSEA analysis showed that CCT3 expression was associated with JAK-STAT3 pathway, Hippo signaling pathway, and WNT signaling pathway. In addition, different expressed genes analysis revealed MYC, which was one of the downstream genes regulated by JAK-STAT3 pathway, was upregulated in MM. This confirms that JAK-STAT3 signaling pathway may promote the progress of disease which was regulated by CCT3 expression. Our study revealed that CCT3 may play a supporting role at the diagnosis of myeloid, and high expression of CCT3 suggested poor prognosis in MM. CCT3 expression may promote the progression of MM mainly by regulating MYC through JAK-STAT3 signaling pathway.
基金：
Xinjiang Joint Fund of National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [U1903117]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81500118, 81600089]
第一作者单位：[1]Department of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China[2]Translational Medicine Center, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China
通讯作者：
通讯机构：[1]Department of Hematology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China[2]Translational Medicine Center, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China[3]Translational Medicine Center, Huaihe Hospital of Henan University, Kaifeng 475000, China[4]Department of Hematology, Huaihe Hospital of Henan University, Kaifeng 475000, China
推荐引用方式(GB/T 7714)：
Tingting Qian,Longzhen Cui,Yan Liu,et al.High expression of chaperonin-containing TCP1 subunit 3 may induce dismal prognosis in multiple myeloma[J].PHARMACOGENOMICS JOURNAL.2020,20(4):563-573.doi:10.1038/s41397-019-0145-6.
APA：
Tingting Qian,Longzhen Cui,Yan Liu,Zhiheng Cheng,Liang Quan...&Chaozeng Si.(2020).High expression of chaperonin-containing TCP1 subunit 3 may induce dismal prognosis in multiple myeloma.PHARMACOGENOMICS JOURNAL,20,(4)
MLA：
Tingting Qian,et al."High expression of chaperonin-containing TCP1 subunit 3 may induce dismal prognosis in multiple myeloma".PHARMACOGENOMICS JOURNAL 20..4(2020):563-573
